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Invitrogen

NGF Polyclonal Antibody

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NGF Polyclonal Antibody

Product Details

PA1-18379

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000-1:5,000
-

ELISA (ELISA)

1:15,000
-
Product Specifications

Species Reactivity

Avian, Human, Mouse, Rat

Host/Isotype

Sheep / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Native mouse beta NGF purified from submaxillary salivary gland.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_1077260

Product Specific Information

Reconstitute in 250 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles. Glycerol (1:1) may be added for an additional stability.

Target Information

Nerve growth factor (NGF) influences the survival and differentiation of a variety of neuronal and nonneuronal cells. The actions of this polypeptide result from binding to specific cell surface receptors which are present as both high and low affinity sites. Although both types of receptor bind NGF only the high affinity form is capable of signal transduction. Cross-linking studies with 125I-NGF have shown that the high affinity receptor of rat PC12 cells forms an Mr 158,000 complex with NGF while the low affinity receptor forms an Mr 100,000 complex. Full length cDNA clones for both the human and rat NGF receptor genes have been produced and sequenced, revealing greater than 90% homology between the two species. NGF exhibits nerve growth stimulating activity and is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Further, NGF stimulates division and differentiation of sympathetic and embryonic sensory neurons. Mutations in the NGF gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of NGF gene expression is associated with allergic rhinitis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: B nerve growth factor; b-NGF; beta ngf; Beta-nerve growth factor; Beta-NGF; BetaNGF; bNGF; MGC161426; MGC161428; Nerve growth factor; nerve growth factor (beta polypeptide); nerve growth factor, beta; nerve growth factor, beta subunit; NGF b; NGF β; NGFB; NGFbeta; NGFβ; pro-nerve growth factor long; unnamed protein product; β nerve growth factor; β NGF; βNGF

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Gene Aliases: Beta-NGF; HSAN5; NGF; NGFB

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UniProt ID: (Human) P01138, (Mouse) P01139, (Rat) P25427

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Entrez Gene ID: (Human) 4803, (Mouse) 18049, (Rat) 310738

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Function(s)
enzyme inhibitor activity receptor binding nerve growth factor receptor binding protein binding growth factor activity metalloendopeptidase inhibitor activity lipid binding cysteine-type endopeptidase activator activity involved in apoptotic process transmembrane receptor protein tyrosine kinase activator activity peptidase inhibitor activity death receptor agonist activity receptor signaling protein activity molecular_function neurotrophic factor
Process(es)
signal transduction transmembrane receptor protein tyrosine kinase signaling pathway peripheral nervous system development circadian rhythm negative regulation of cell proliferation extrinsic apoptotic signaling pathway via death domain receptors positive regulation of gene expression positive regulation of neuron projection development positive regulation of neuron maturation sensory perception of pain nerve development neuron projection development positive regulation of protein ubiquitination nerve growth factor signaling pathway negative regulation of neuron apoptotic process regulation of neuron differentiation positive regulation of neuron differentiation positive regulation of axon extension positive regulation of Ras protein signal transduction regulation of neurotransmitter secretion neurotrophin TRK receptor signaling pathway positive regulation of collateral sprouting axon extension neuron projection morphogenesis modulation of synaptic transmission regulation of release of sequestered calcium ion into cytosol neuron apoptotic process positive regulation of protein kinase B signaling positive regulation of ERK1 and ERK2 cascade extrinsic apoptotic signaling pathway in absence of ligand cell-cell signaling memory positive regulation of cell proliferation adult locomotory behavior negative regulation of peptidase activity negative regulation of endopeptidase activity positive regulation of cell growth positive regulation of protein autophosphorylation intracellular signal transduction positive regulation of sequence-specific DNA binding transcription factor activity positive regulation of neurotrophin TRK receptor signaling pathway cellular response to acid chemical positive regulation of stem cell proliferation negative regulation of type B pancreatic cell apoptotic process inflammatory response aging response to radiation response to mechanical stimulus response to organic substance response to ozone response to organic cyclic compound response to lipopolysaccharide response to nicotine response to drug response to peptide hormone response to glucocorticoid response to electrical stimulus
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