Search
Abnova
NIP Polyclonal Antibody, MaxPab™
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
H00090527-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NIP (AAH20841, 1 a.a. approximately 298 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.49 mg/mL
Amount
50 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MATLGHTFPF YAGPKPTFPM DTTLASIIMI FLTALATFIV ILPGIRGKTR LFWLLRVVTS LFIGAAILGT PVQQLNETIN YNEEFTWRLG ENYAEEYAKA LEKGLPDPVL YLAEKFTPRS PCGLYRQYRL AGHYTSAMLW VAFLCWLLAN VMLSMPVLVY GGYMLLATGI FQLLALLFFS MATSLTSPCP LHLGASVLHT HHGPAFWITL TTGLLCVLLG LAMAVAHRMQ PHRLKAFFNQ SVDEDPMLEW SPEEGGLLSP RYRSMADSPK SQDIPLSEAS STKAYCKEAH PKDPDCAL
Target Information
Dual oxidases DUOX1 and DUOX2 are NADPH oxidases which are involved in hydrogen peroxide production necessary for thyroid hormonogenesis. They form a heterodimer with specific maturation factors DUOXA1 and DUOXA2, respectively, which is essential for the maturation and function of the DUOX enzyme complexes. This gene encodes the DUOX1 activator or maturation factor DUOXA1. Rat studies identified a bidirectional promoter which controls the transcription of the DUOX1 and DUOXA1 genes. This protein is cotransported to the cell surface when coexpressed with DUOX1 and is retained in the endoplasmic reticulum when expressed without DUOX1 protein. The expression of this gene or the DUOX1 gene is not suppressed by thyroglobulin (Tg), a macromolecular precursor in thyroid hormone synthesis, while the expression of the DUOX2 and DUOXA2 are significantly suppressed by the Tg. This protein is also a p53-regulated neurogenic factor involved in p53 dependent neuronal differentiation. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: Dual oxidase activator 1; Dual oxidase maturation factor 1; dual oxidase maturation factor 1 alpha; dual oxidase maturation factor 1 beta; dual oxidase maturation factor 1 delta; dual oxidase maturation factor 1 gamma; duoxa1 alpha; duoxa1 beta; inactive variant; duoxa1 delta; inactive variant; duoxa1 gamma; homolog of Drosophila Numb-interacting protein; Numb-interacting protein; unnamed protein product
Gene Aliases: DUOXA1; mol; NIP; NUMBIP
UniProt ID: (Human) Q1HG43
Entrez Gene ID: (Human) 90527
protein localization
positive regulation of hydrogen peroxide biosynthetic process
protein transport
hydrogen peroxide metabolic process
positive regulation of neuron differentiation
regulation of inflammatory response
positive regulation of reactive oxygen species metabolic process
regulation of thyroid hormone generation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support