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| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:500-1:1,000 | View 1 publication 1 publication |
Immunohistochemistry (IHC) |
- | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:50-1:500 | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
NIT1 Fusion Protein Ag5764 (1-243 aa encoded by BC046149) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.15 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MLGFITRPP HRFLSLLCPG LRIPQLSVLC AQPRPRAMAI SSSSCELPLV AVCQVTSTPD KQQNFKTCAE LVREAARLGP CLAFLPEAFD FIARDPAETL HLSEPLGGKL LEEYTQLARE CGLWLSLGGF HERGQDWEQT QKIYNCHVLL NSKGAVVATY RKTHLCDVEI PGQGPMCESN STMPGPSLES PVSTPAGKIG LAVCYDMRFP ELSLALAQAG AEILTYPSAF GSITGPAHWE PVSS (1-243 aa encoded by BC046149)
Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Deaminated glutathione amidase; dGSH amidase; MGC57670; Nitrilase homolog 1
Gene Aliases: AI255805; ESTM30; NIT1; rCG_20134; W57327
UniProt ID: (Human) Q86X76, (Rat) Q7TQ94, (Mouse) Q8VDK1
Entrez Gene ID: (Human) 4817, (Rat) 289222, (Mouse) 27045
Molecular Function:
hydrolase
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