Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Deaminated glutathione amidase; dGSH amidase; NIT1; nitrilase 1; Nitrilase homolog 1
Gene Aliases: AI255805; ESTM30; NIT1; rCG_20134; W57327
Molecular Function: hydrolase