Immunogen sequence: MAWMLLLILI MVHPGSCALW VSQPPEIRTL EGSSAFLPCS FNASQGRLAI GSVTWFRDEV VPGKEVRNGT PEFRGRLAPL ASSRFLHDHQ AELHIRDVRG; Positive Samples: K-562, Raji, HP-1, H460, Mouse spleen, Mouse thymus, Mouse lung, Rat thymus; Cellular Location: Cell membrane, Single-pass type I membrane protein
The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria susceptibility. Three transcript variants encoding different isoforms have been found for this gene.
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Protein Aliases: Activating natural killer receptor p30; activating NK-A1 receptor; CD337; lymphocyte antigen 117; Natural cytotoxicity triggering receptor 3; Natural killer cell p30-related protein; NK receptor 1c7; NK-p30
Gene Aliases: 1C7; CD337; LY117; MALS; NCR3; NKp30
UniProt ID: (Human) O14931