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Bioss

NLGN1/NLGN2 Polyclonal Antibody

View all (2) Neuroligin 1/2 antibodies

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Product Details

BS-11098R

Applications
Tested Dilution
Publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:500
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:100-1:500
-

Flow Cytometry (Flow)

1:100
-

ELISA (ELISA)

1:5,000-1:10,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human NLGN2.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Neuroligins are a family of plasma membrane proteins that possess an N-terminal hydrophobic domain, a large esterase homology domain, a single transmembrane region, a short cytoplasmic domain, and an EF-hand binding domain (1,2). Members of the neuroligin family include Neuroligin 1, Neuroligin 2 and Neuroligin 3. Neuroligins are expressed in excitatory neuronal synaptic clefts. Neuroligins play a role in the formation and remodeling of CNS synapses by binding to b-neurexins, a family of neuronal cell surface proteins. Neuroexin 1b binds to the EF-hand domain of Neuroligin 1 and requires calcium ion. Neuroligins also bind to PSD-95, which may recruit ion channels and neurotransmitter receptors to the synapses.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: HLN2; Neuroligin I; Neuroligin-1; Neuroligin-2; ortholog of human and rat neuroligin 2 NLGN2; unnamed protein product

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Gene Aliases: 6330415N05Rik; BB179718; KIAA1070; KIAA1366; mKIAA1070; NL1; NL2; NLG1; NLGN1; NLGN2

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UniProt ID: (Human) Q8N2Q7, (Human) Q8NFZ4, (Mouse) Q99K10, (Rat) Q62765, (Rat) Q62888, (Mouse) Q69ZK9

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Entrez Gene ID: (Human) 22871, (Human) 57555, (Mouse) 192167, (Rat) 116647, (Rat) 117096, (Mouse) 216856

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Function(s)
beta-amyloid binding PDZ domain binding signaling receptor activity neurexin family protein binding identical protein binding cell adhesion molecule binding scaffold protein binding receptor activity protein binding protein dimerization activity carboxylic ester hydrolase activity cell adhesion molecule
Process(es)
protein targeting cell adhesion heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules neuron cell-cell adhesion nervous system development synapse assembly positive regulation of circadian sleep/wake cycle, wakefulness synaptic vesicle targeting calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules neuronal signal transduction neuron projection development positive regulation of synaptic transmission, GABAergic protein localization to synapse establishment of protein localization regulation of neuron differentiation rhythmic process cytoskeletal matrix organization at active zone neuron projection morphogenesis modulation of synaptic transmission positive regulation of filopodium assembly positive regulation of synapse assembly positive regulation of synaptic transmission, glutamatergic positive regulation of dendritic spine development negative regulation of dendritic spine morphogenesis cellular response to calcium ion terminal button organization synaptic vesicle clustering postsynaptic membrane assembly presynaptic membrane assembly AMPA glutamate receptor clustering NMDA glutamate receptor clustering neurexin clustering involved in presynaptic membrane assembly postsynaptic density protein 95 clustering receptor localization to synapse NMDA selective glutamate receptor signaling pathway AMPA selective glutamate receptor signaling pathway presynapse assembly neuron projection arborization positive regulation of ruffle assembly positive regulation of neuromuscular synaptic transmission positive regulation of synaptic vesicle endocytosis positive regulation of intracellular signal transduction excitatory synapse assembly positive regulation of synaptic vesicle exocytosis positive regulation of excitatory postsynaptic potential thigmotaxis regulation of respiratory gaseous exchange by neurological system process jump response positive regulation of cell proliferation sensory perception of pain positive regulation of insulin secretion protein localization to cell surface social behavior locomotory exploration behavior cell-cell junction maintenance synapse organization neuromuscular process controlling balance synaptic transmission, GABAergic neurotransmitter-gated ion channel clustering gephyrin clustering involved in postsynaptic density assembly positive regulation of inhibitory postsynaptic potential cell-cell adhesion postsynaptic specialization assembly insulin metabolic process positive regulation of protein localization to synapse positive regulation of t-SNARE clustering inhibitory synapse assembly regulation of presynapse assembly positive regulation of synaptic vesicle clustering synaptic vesicle transport protein homooligomerization protein heterotetramerization inhibitory postsynaptic potential long-term synaptic potentiation regulation of N-methyl-D-aspartate selective glutamate receptor activity regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity metabolic process neuronal ion channel clustering
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