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Product Details
PA5-61758
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human NALP6. Recombinant protein control fragment (Product #RP-97486).
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2644457
Product Specific Information
Immunogen sequence: TLSHCKLPDA VCRDLSEALR AAPALTELGL LHNRLSEAGL RMLSEGLAWP QCRVQTVRVQ LPDPQRGLQY LVGMLRQSPA LTTLDLSGCQ LPAPMVTYLC AVL
Highest antigen sequence identity to the following orthologs: Mouse - 69%, Rat - 71%.
Target Information
NALP proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins and are thought to be involved in inflammation and reproduction. NALP6, also known as PYPAF5, is highly expressed in granulocytes and T cells and co-localizes with the PYRIN-CARD protein ASC. Co-expression of NALP6 with ASC results in a synergistic activation of NF-kappa-B and activated caspase-1-dependent cytokine processing, suggesting that NALP6 functions in immune cells to coordinate the transduction of pro-inflammatory signals.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Angiotensin II/vasopressin receptor; NACHT, leucine rich repeat and PYD containing 6; NACHT, LRR and PYD domains-containing protein 6; NLR family, pyrin domain containing 6; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6; PYRIN-containing APAF1-like protein 5
Gene Aliases: AVR; CLR11.4; NALP6; NAVR; NAVR/AVR; NLRP6; PAN3; PYPAF5
UniProt ID: (Human) P59044
Entrez Gene ID: (Human) 171389
negative regulation of inflammatory response to antigenic stimulus
inflammatory response
G-protein coupled receptor signaling pathway
response to bacterium
regulation of autophagy
negative regulation of toll-like receptor signaling pathway
wound healing
negative regulation of I-kappaB kinase/NF-kappaB signaling
innate immune response
regulation of inflammatory response
regulation of mucus secretion
negative regulation of ERK1 and ERK2 cascade
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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