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Invitrogen

NMDAR2A Polyclonal Antibody

5 Published Figures
7 References
View all (46) NMDAR2A antibodies

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NMDAR2A Polyclonal Antibody

Product Details

PA5-35377

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
View 6 publications 6 publications

Immunohistochemistry (IHC)

1:1,000
-

Immunoprecipitation (IP)

3 µL / 200 µg lysate
-

Immunomicroscopy (IM)

-
View 1 publication 1 publication
Product Specifications

Species Reactivity

Human, Mouse, Rabbit, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Fusion protein from the C-terminal region of the NR2A subunit of rat GRIN2A
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

~0.2 mg/mL

Purification

Affinity chromatography

Storage buffer

0.01M HEPES, pH 7.5, with 50% glycerol, 0.15M NaCl, 0.1mg/mL BSA

Contains

no preservative

Storage conditions

-20°C

RRID

AB_2552687

Product Specific Information

PA5-35377 will not cross-react with NR2B and NR2C subunits.

This antibody contains enough material to conduct 10 mini-Western blots.

Target Information

N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate-gated ion channels. These receptors have been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C) and NMDAR2D (GRIN2D). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: glutamate [NMDA] receptor subunit epsilon-1; glutamate ionotropic receptor NMDA 2A; glutamate receptor; glutamate receptor, ionotropic, N-methyl D-aspartate 2A; hNR2A; N-methyl D-aspartate receptor subtype 2A; N-methyl-D-aspartate receptor channel, subunit epsilon-1; N-methyl-D-aspartate receptor subunit 2A; NMDA Receptor 2A; NMDAR 2A; OTTHUMP00000160135; OTTHUMP00000174531; unnamed protein product

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Gene Aliases: EPND; FESD; GluN2A; GluRepsilon1; LKS; NMDAR2A; NR2A

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UniProt ID: (Human) Q12879, (Rat) Q00959, (Mouse) P35436

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Entrez Gene ID: (Rabbit) 100337889, (Human) 2903, (Rat) 24409, (Mouse) 14811

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Function(s)
beta-amyloid binding NMDA glutamate receptor activity ion channel activity cation channel activity calcium channel activity protein binding zinc ion binding ligand-gated ion channel activity glutamate-gated calcium ion channel activity signaling receptor activity transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential ionotropic glutamate receptor activity receptor binding extracellular-glutamate-gated ion channel activity glutamate binding protein kinase binding voltage-gated cation channel activity glutamate receptor binding macromolecular complex binding calcium-dependent protein binding cell adhesion molecule binding ATPase binding scaffold protein binding ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential protein tyrosine kinase binding transmembrane signal receptor
Process(es)
ion transport glutamate receptor signaling pathway chemical synaptic transmission brain development learning or memory calcium-mediated signaling ionotropic glutamate receptor signaling pathway synaptic transmission, glutamatergic sodium ion transmembrane transport response to ethanol regulation of synaptic plasticity regulation of neuronal synaptic plasticity modulation of synaptic transmission positive regulation of synaptic transmission, glutamatergic excitatory postsynaptic potential long-term synaptic potentiation calcium ion transmembrane transport calcium ion transmembrane import into cytosol cation transmembrane transport excitatory chemical synaptic transmission regulation of cation transmembrane transport cellular response to beta-amyloid positive regulation of excitatory postsynaptic potential action potential receptor recycling startle response response to amphetamine calcium ion transport positive regulation of cytosolic calcium ion concentration learning memory associative learning visual learning response to xenobiotic stimulus response to light stimulus response to wounding response to carbohydrate response to manganese ion response to lithium ion response to lead ion response to amine sensory perception of pain spinal cord development mesencephalic trigeminal nucleus development hippocampus development cerebral cortex development neurogenesis sleep auditory behavior regulation of ARF protein signal transduction directional locomotion multicellular organismal response to stress response to nicotine locomotion negative regulation of protein catabolic process response to cocaine regulation of membrane potential dopamine metabolic process serotonin metabolic process positive regulation of apoptotic process regulation of long-term neuronal synaptic plasticity positive regulation of mitochondrial calcium ion concentration response to calcium ion response to methylmercury response to other organism regulation of postsynaptic membrane potential response to ammonium ion response to fungicide cellular response to amino acid stimulus cellular response to magnesium ion cellular response to manganese ion cellular response to zinc ion cellular response to dsRNA cellular response to growth factor stimulus cellular response to lipid positive regulation of protein targeting to membrane response to environmental enrichment dendritic spine organization positive regulation of inhibitory postsynaptic potential modulation of excitatory postsynaptic potential regulation of presynaptic membrane potential neurotransmitter receptor transport, plasma membrane to endosome regulation of response to alcohol response to glycoside protein localization to postsynaptic membrane response to hydrogen sulfide cellular response to glycine conditioned place preference regulation of N-methyl-D-aspartate selective glutamate receptor activity locomotory behavior rhythmic process neuromuscular process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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