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Invitrogen
NOS1AP Polyclonal Antibody
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FIGURE: 1 / 4
NOS1AP Antibody (PA5-143893) in IHC (P)
Immunohistochemistry analysis of NOS1AP in paraffin-embedded section of mouse brain tissue. Heat mediated antigen retrieval was performed in EDTA buffer (pH 8.0, epitope retrieval solution). The tissue section was blocked with 10% goat serum. Samples were incubated with NOS1AP Polyclonal antibody (Product # PA5-143893) using a dilution of 2 μg/mL overnight at 4°C. Peroxidase Conjugated Goat Anti-rabbit IgG ... View More
Product Details
PA5-143893
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
E.coli-derived human CAPON/NOS1AP recombinant protein (Position: D24-D438).
Conjugate
Form
Lyophilized
Concentration
500 µg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 4mg trehalose
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Adding 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
Positive Control - WB: human Hela whole cell, human A431 whole cell, human Hacat whole cell, human MCF-7 whole cell, rat brain tissue, mouse brain tissue. IHC: mouse brain tissue, rat brain tissue. Flow: HEL cell.|Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.
Target Information
This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: C-terminal PDZ domain ligand of neuronal nitric oxide synthase; C-terminal PDZ domain ligand of neuronal nitric oxide synthase (CAPON); C-terminal PDZ ligand of neuronal nitric oxide synthase protein; Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein; ligand of neuronal nitric oxide synthase with carboxyl-terminal PDZ domain; MGC138500; nitric oxide synthase 1 (neuronal) adaptor protein; Nitric oxide synthase 1 adaptor protein
Gene Aliases: 6330408P19Rik; CAPON; KIAA0464; NOS1AP
UniProt ID: (Human) O75052, (Mouse) Q9D3A8, (Rat) O54960
Entrez Gene ID: (Human) 9722, (Mouse) 70729, (Rat) 192363
regulation of heart rate by chemical signal
positive regulation of gene expression
positive regulation of nitric oxide mediated signal transduction
regulation of apoptotic process
regulation of nitric oxide biosynthetic process
positive regulation of nitric oxide biosynthetic process
regulation of nitric-oxide synthase activity
positive regulation of nitric-oxide synthase activity
regulation of ventricular cardiac muscle cell membrane repolarization
regulation of cardiac muscle cell action potential
positive regulation of potassium ion transmembrane transport
regulation of high voltage-gated calcium channel activity
positive regulation of delayed rectifier potassium channel activity
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
positive regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
positive regulation of peptidyl-cysteine S-nitrosylation
biological_process
negative regulation of neuron death
neurotransmitter secretion
neuron projection regeneration
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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