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Invitrogen

NOTCH2 (Cleaved Ala1734) Polyclonal Antibody

View all (2) NOTCH2 (Cleaved Ala1734) antibodies

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NOTCH2 (Cleaved Ala1734) Polyclonal Antibody

Product Details

PA5-99429

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:2,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:200
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

A synthesized peptide derived from human NOTCH2(Accession Q04721), corresponding to amino acid residues N1723-T1752.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Affinity chromatography

Storage buffer

PBS, pH 7.4, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

RRID

AB_2818362

Product Specific Information

Antibody detects endogenous levels of fragment of activated Notch2 resulting from cleavage adjacent to Ala1734.

Target Information

The LIN-12/Notch family of transmembrane receptors is believed to play a central role in development by regulating cell fate decisions. To date, four Notch homologs have been identified in mammals and have been designated Notch 1, Notch 2, Notch 3 and Notch 4. The Notch genes are expressed in a variety of tissues in both the embryonic and adult organism, suggesting that the genes are involved in multiple signaling pathways. The Notch proteins have been found to be overexpressed or rearranged in human tumors. Ligands for Notch include Jagged, Jagged2 and Delta. Jagged can activate Notch and prevent myoblast differentiation by inhibiting the expression of muscle regulatory and structural genes. Jagged2 is thought to be involved in the development of various tissues whose development is dependent upon epithelial-mesenchymal interactions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: membrane bound receptor; Motch B; Neurogenic locus notch homolog protein 2; Notch 2; Notch gene homolog 2; Notch homolog 2; putative cell-fate determining protein; transmembrane protein; unnamed protein product

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Gene Aliases: AGS2; AI853703; HJCYS; hN2; N2; NOTCH2

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UniProt ID: (Human) Q04721, (Mouse) O35516

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Entrez Gene ID: (Human) 4853, (Mouse) 18129, (Rat) 29492

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Function(s)
transcription coactivator activity calcium ion binding protein binding enzyme binding signaling receptor activity NF-kappaB binding receptor activity cell adhesion molecule
Process(es)
negative regulation of transcription from RNA polymerase II promoter in utero embryonic development cell fate determination liver development placenta development heart looping morphogenesis of an epithelial sheet marginal zone B cell differentiation inflammatory response to antigenic stimulus atrioventricular node development pulmonary valve morphogenesis regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter apoptotic process humoral immune response Notch signaling pathway determination of left/right symmetry nervous system development axon guidance cell proliferation positive regulation of cell proliferation organ morphogenesis negative regulation of macromolecule biosynthetic process negative regulation of gene expression positive regulation of keratinocyte proliferation hemopoiesis cell differentiation embryonic limb morphogenesis BMP signaling pathway positive regulation of BMP signaling pathway multicellular organism growth intracellular signal transduction intrahepatic bile duct development wound healing defense response to bacterium regulation of apoptotic process myeloid dendritic cell differentiation positive regulation of apoptotic process negative regulation of apoptotic process positive regulation of osteoclast differentiation positive regulation of transcription from RNA polymerase II promoter positive regulation of Ras protein signal transduction bone remodeling regulation of developmental process positive regulation of smooth muscle cell differentiation cardiac septum morphogenesis atrial septum morphogenesis placenta blood vessel development ciliary body morphogenesis positive regulation of ERK1 and ERK2 cascade left/right axis specification cellular response to tumor cell proximal tubule development glomerular visceral epithelial cell development glomerular capillary formation hepatocyte proliferation liver morphogenesis positive regulation of pri-miRNA transcription from RNA polymerase II promoter regulation of hemopoiesis cholangiocyte proliferation regulation of osteoclast development transcription, DNA-templated cell cycle arrest multicellular organism development negative regulation of cell proliferation cell growth interleukin-4 secretion tissue regeneration
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