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Rockland
NOX1 Polyclonal Antibody
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FIGURE: 1 / 3
NOX1 Antibody (600-401-DD8) in ICC/IF
Immunofluorescence Microscopy of Rabbit anti-NOX1 antibody. Tissue: human kidney. Primary antibody: NOX1 antibody at 20 µg/mL. Secondary antibody: Fluorescein rabbit secondary antibody at 1:20,000. Localization: NOX1 is located on the membrane. Staining: NOX1 as red fluorescent signal.
Product Details
600-401-DD8
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Anti-NOX1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid peptide near the internal region of human NOX1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.2
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Three splice variants of NOX1 have been identified, NOH-1L, NOH-1S and NOH-1Lv. NOH-1S is a voltage-gated proton channel that participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H (+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. NOX1 have the potential to be effective treatments for a range of ischemic diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating); Mitogenic oxidase 1; MOX-1; Mox1; similar to gp91phox; NADH/NADPH mitogenic oxidase subunit P65-MOX; NADPH oxidase 1; NADPH oxidase homolog-1; NOH-1; NOH-1L; NOH-1Lv; NOH-1S; NOX-1; NOX1; unnamed protein product
Gene Aliases: GP91-2; MOX1; NOH-1; NOH-1L; NOH1; NOX1
UniProt ID: (Human) Q9Y5S8
Entrez Gene ID: (Human) 27035
MAPK cascade
angiogenesis
regulation of systemic arterial blood pressure by renin-angiotensin
NADP metabolic process
defense response
inflammatory response
signal transduction
JNK cascade
regulation of blood pressure
positive regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to oxidative stress
positive regulation of vascular endothelial growth factor production
cell migration
extracellular matrix organization
superoxide anion generation
hydrogen peroxide metabolic process
positive regulation of MAPK cascade
positive regulation of integrin biosynthetic process
respiratory burst
positive regulation of JNK cascade
positive regulation of smooth muscle cell proliferation
cellular response to hyperoxia
oxygen metabolic process
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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