Search
Invitrogen
NOX1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
PA5-120150
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide
Conjugate
Form
Liquid
Concentration
2.19 mg/mL
Amount
219 µg
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.09% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Positive test controls include: HT-29, 22Rv1. The target is usually found in the following locations: Cell projection, Multi-pass membrane protein, invadopodium membrane.
Target Information
Voltage-gated proton (hydrogen) channels play an important role in cellular defense against acidic stress. NOX1 is a homolog of the catalytic subunit of the superoxide-generating NADPH oxidase of phagocytes, gp91phox. Three splice variants of NOX1 have been identified, NOH-1L, NOH-1S and NOH-1Lv. NOH-1S is a voltage-gated proton channel that participates in the regulation of cellular pH and is blocked by zinc. NOH-1L is a pyridine nucleotide-dependent oxidoreductase that generates superoxide and might conduct H (+) ions as part of its electron transport mechanism, whereas NOH-1S does not contain an electron transport chain. NOX1 have the potential to be effective treatments for a range of ischemic diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: mitogenic oxidase (pyridine nucleotide-dependent superoxide-generating); Mitogenic oxidase 1; MOX-1; Mox1; similar to gp91phox; NADH/NADPH mitogenic oxidase subunit P65-MOX; NADPH oxidase 1; NADPH oxidase homolog-1; NOH-1; NOH-1L; NOH-1Lv; NOH-1S; NOX-1; NOX1; unnamed protein product
Gene Aliases: GP91-2; MOX1; NOH-1; NOH-1L; NOH1; NOX1
UniProt ID: (Human) Q9Y5S8
Entrez Gene ID: (Human) 27035
MAPK cascade
angiogenesis
regulation of systemic arterial blood pressure by renin-angiotensin
NADP metabolic process
defense response
inflammatory response
signal transduction
JNK cascade
regulation of blood pressure
positive regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to oxidative stress
positive regulation of vascular endothelial growth factor production
cell migration
extracellular matrix organization
superoxide anion generation
hydrogen peroxide metabolic process
positive regulation of MAPK cascade
positive regulation of integrin biosynthetic process
respiratory burst
positive regulation of JNK cascade
positive regulation of smooth muscle cell proliferation
cellular response to hyperoxia
oxygen metabolic process
positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support