Keep as concentrated solution.
Predicted reactivity: Mouse (93%), Rat (93%), Bovine (96%).
Positive Control: 293T, HeLa, A431, Jurkat, Raji, unboiled NOX4-transfected 293T.
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Oxygen sensing is essential for homeostasis in all aerobic organisms. A phagocyte-type oxidase, similar to that responsible for the production of large amounts of reactive oxygen species (ROS) in neutrophil granulocytes, with resultant antimicrobial activity, has been postulated to function in the kidney as an oxygen sensor that regulates the synthesis of erythropoietin in the renal cortex. NOX4 has a role as a redox messenger in the activation of intracellular signaling pathways leading (or contributing) to mitochondriogenesis, cell survival, and differentiation in hematopoietic stem cells. Data suggests that NOX4 provides a novel link between the insulin receptor and the generation of cellular reactive oxygen species that enhances insulin signal transduction.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Kidney oxidase-1; Kidney superoxide-producing NADPH oxidase; KOX-1; KOX1; NADPH oxidase 4; NOX 4; NOX-4; Renal NAD(P)H-oxidase; Superoxide-generating NADPH oxidase 4
Gene Aliases: AI648021; KOX; KOX-1; NOX4; RENOX