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Proteintech
NQO1 Polyclonal Antibody
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Product Details
11451-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human,
Mouse,
Pig,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NQO1 Fusion Protein Ag2009 (1-274 aa encoded by BC007659)
Conjugate
Form
Liquid
Concentration
0.19 mg/mL
Amount
28.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody recognizes all the three isoforms (26-27 kDa and 31 kDa) of NQO1 and the homo-dimer form (66-70 kDa) of NQO1.
Immunogen sequence: MVGRRALIV LAHSERTSFN YAMKEAAAAA LKKKGWEVVE SDLYAMNFNP IISRKDITGK LKDPANFQYP AESVLAYKEG HLSPDIVAEQ KKLEAADLVI FQFPLQWFGV PAILKGWFER VFIGEFAYTY AAMYDKGPFR SKKAVLSITT GGSGSMYSLQ GIHGDMNVIL WPIQSGILHF CGFQVLEPQL TYSIGHTPAD ARIQILEGWK KRLENIWDET PLYFAPSSLF DLNFQAGFLM KKEVQDEEKN KKFGLSVGHH LGKSIPTDNQ IKARK (1-274 aa encoded by BC007659)
Target Information
NQO1 is a member of the NAD(P)H dehydrogenase (quinone) family and a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Altered expression of the protein has been seen in many tumors and is also associated with Alzheimer's disease (AD).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Azoreductase; diaphorase (NADH/NADPH) (cytochrome b-5 reductase); Diaphorase 4; diaphorase-4; dioxin-inducible 1; DT-diaphorase; DTD; Menadione reductase; NAD(P)H dehydrogenase [quinone] 1; NAD(P)H dehydrogenase, quinone 1; NAD(P)H-quinone oxidoreductase; NAD(P)H:menadione oxidoreductase 1; NAD(P)H:Quinone acceptor oxidoreductase type 1; NAD(P)H:quinone oxidoreductase 1; NAD(P)H:quinone oxireductase; NQ01; Phylloquinone reductase; QR1; Quinone reductase 1; unnamed protein product
Gene Aliases: DHQU; DIA4; DTD; NMOR1; NMORI; NQO1; QR1
UniProt ID: (Human) P15559
Entrez Gene ID: (Human) 1728
protein polyubiquitination
ubiquinone metabolic process
xenobiotic metabolic process
nitric oxide biosynthetic process
response to oxidative stress
synaptic transmission, cholinergic
response to toxic substance
removal of superoxide radicals
protein catabolic process
response to lipopolysaccharide
cellular response to oxidative stress
negative regulation of protein catabolic process
vitamin E metabolic process
vitamin K metabolic process
innate immune response
cell redox homeostasis
response to caloric restriction
negative regulation of ferroptosis
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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