This target displays homology in the following species: Cow: 92%; Dog: 75%; Guinea Pig: 92%; Horse: 83%; Human: 100%; Mouse: 92%; Rabbit: 92%; Rat: 92%
This gene encodes a protein that contains a DNA-binding domain. The encoded protein acts as a dominant-negative regulator of transcription which is mediated by the retinoic acid receptor. This protein also functions as an anti-testis gene by acting antagonistically to Sry. Mutations in this gene result in both X-linked congenital adrenal hypoplasia and hypogonadotropic hypogonadism.
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Protein Aliases: adrenal hypoplasia, congenital homolog; DAX 1; DSS-AHC critical region on the X chromosome protein 1; nuclear hormone receptor; Nuclear receptor DAX-1; Nuclear receptor subfamily 0 group B member 1; nuclear receptor subfamily 0, group B, member 1; orphan nuclear receptor DAX-1; R0B1
Gene Aliases: AHC; AHCH; AHX; BOS_26183; DAX-1; DAX1; DSS; GTD; HHG; NR0B1; NROB1; SRXY2