Search
Proteintech
NR1D1 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
14506-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Published species
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NR1D1 Fusion Protein Ag5964 (1-350 aa encoded by BC056148)
Conjugate
Form
Liquid
Concentration
0.26 mg/mL
Amount
39 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This is a rabbit polyclonal antibody raised against the N terminus of human NR1D1.
Immunogen sequence: MTTLDSNNN TGGVITYIGS SGSSPSRTSP ESLYSDNSNG SFQSLTQGCP TYFPPSPTGS LTQDPARSFG SIPPSLSDDG SPSSSSSSSS SSSSFYNGSP PGSLQVAMED SSRVSPSKST SNITKLNGMV LLCKVCGDVA SGFHYGVHAC EGCKGFFRRS IQQNIQYKRC LKNENCSIVR INRNRCQQCR FKKCLSVGMS RDAVRFGRIP KREKQRMLAE MQSAMNLANN QLSSQCPLET SPTQHPTPGP MGPSPPPAPV PSPLVGFSQF PQQLTPPRSP SPEPTVEDVI SQVARAHREI FTYAHDKLGS SPGNFNANHA SGSPPATTPH RWENQGCPPA PNDNNTLAAQ R (1-350 aa encoded by BC056148)
Target Information
This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BD73; EAR-1; EAR-1R; nuclear receptor protein; nuclear receptor Rev-ErbA-alpha; Nuclear receptor subfamily 1 group D member 1; orphan nuclear receptor; rev-erb alpha; Rev-erba; rev-erbA alpha; rev-erbA(alpha); Rev-erbA-alpha; Rev-ErbA-alpha protein; Rev-ErbAalpha; REV-ERBalpha; Reverbaalpha; RVR; unnamed protein product; V-erbA-related protein 1
Gene Aliases: A530070C09Rik; ear-1; EAR1; HREV; NR1D1; R75201; REVERBA; REVERBalpha; THRA1; THRAL
UniProt ID: (Human) P20393, (Mouse) Q3UV55
Entrez Gene ID: (Human) 9572, (Mouse) 217166
transcription regulatory region sequence-specific DNA binding
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcription corepressor binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
heme binding
sequence-specific DNA binding
metal ion binding
E-box binding
sequence-specific double-stranded DNA binding
core promoter sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription regulatory region DNA binding
C4 zinc finger nuclear receptor
DNA-binding transcription factor
zinc finger transcription factor
gene-specific transcriptional regulator
negative regulation of transcription from RNA polymerase II promoter
cellular glucose homeostasis
glycogen biosynthetic process
regulation of transcription, DNA-templated
circadian rhythm
hormone-mediated signaling pathway
proteasomal protein catabolic process
regulation of lipid metabolic process
cell differentiation
intracellular steroid hormone receptor signaling pathway
intracellular receptor signaling pathway
protein destabilization
circadian regulation of gene expression
negative regulation of toll-like receptor 4 signaling pathway
cholesterol homeostasis
regulation of circadian sleep/wake cycle
regulation of circadian rhythm
negative regulation of I-kappaB kinase/NF-kappaB signaling
response to leptin
regulation of fat cell differentiation
negative regulation of transcription, DNA-templated
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
rhythmic process
negative regulation of inflammatory response
circadian temperature homeostasis
regulation of insulin secretion involved in cellular response to glucose stimulus
regulation of type B pancreatic cell proliferation
negative regulation of astrocyte activation
positive regulation of bile acid biosynthetic process
cellular response to lipopolysaccharide
cellular response to interleukin-1
cellular response to tumor necrosis factor
negative regulation of cold-induced thermogenesis
negative regulation of neuroinflammatory response
negative regulation of microglial cell activation
transcription, DNA-templated
transcription from RNA polymerase II promoter
negative regulation of receptor biosynthetic process
regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter
steroid hormone mediated signaling pathway
regulation of cholesterol homeostasis
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support