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Proteintech

NR1D1 Polyclonal Antibody

5 References
View all (18) NR1D1 antibodies
Datasheet
Protocols
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Datasheet
Protocols
Questions & Answers
Tech Support

Product Details

14506-1-AP

Applications Tested Dilution Publications

Western Blot (WB)

 1:500-1:2,000 View 2 publications 2 publications

Immunocytochemistry (ICC/IF)

 1:50-1:500 View 2 publications 2 publications

Immunoprecipitation (IP)

 0.5-4.0 µg -

ChIP assay (ChIP)

 Assay-dependent View 1 publication 1 publication
Product Specifications

Species Reactivity

 Human, Mouse

Published species

 Human, Mouse

Host/Isotype

 Rabbit / IgG

Class

 Polyclonal

Type

 Antibody

Immunogen

NR1D1 Fusion Protein Ag5964 (1-350 aa encoded by BC056148)
View immunogen

Conjugate

 Unconjugated

Form

 Liquid

Concentration

 0.26 mg/mL

Purification

 Antigen affinity chromatography

Storage buffer

 PBS, pH 7.3, with 50% glycerol

Contains

 0.1% sodium azide

Storage conditions

 -20°C

Product Specific Information

This is a rabbit polyclonal antibody raised against the N terminus of human NR1D1.

Immunogen sequence: MTTLDSNNN TGGVITYIGS SGSSPSRTSP ESLYSDNSNG SFQSLTQGCP TYFPPSPTGS LTQDPARSFG SIPPSLSDDG SPSSSSSSSS SSSSFYNGSP PGSLQVAMED SSRVSPSKST SNITKLNGMV LLCKVCGDVA SGFHYGVHAC EGCKGFFRRS IQQNIQYKRC LKNENCSIVR INRNRCQQCR FKKCLSVGMS RDAVRFGRIP KREKQRMLAE MQSAMNLANN QLSSQCPLET SPTQHPTPGP MGPSPPPAPV PSPLVGFSQF PQQLTPPRSP SPEPTVEDVI SQVARAHREI FTYAHDKLGS SPGNFNANHA SGSPPATTPH RWENQGCPPA PNDNNTLAAQ R (1-350 aa encoded by BC056148)

Target Information

This gene encodes a member of the nuclear hormone receptor family, specifically the NR1 subfamily of receptors. The encoded protein functions as a transcriptional repressor and may play a role in circadian rhythms and carbohydrate and lipid metabolism. Alternatively spliced transcript variants have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: BD73; EAR-1; nuclear receptor protein; nuclear receptor Rev-ErbA-alpha; Nuclear receptor subfamily 1 group D member 1; nuclear receptor subfamily 1, group D, member 1; orphan nuclear receptor; rev-erb alpha; Rev-erba; rev-erbA alpha; rev-erbA(alpha); Rev-erbA-alpha; Rev-ErbA-alpha protein; Rev-ErbAalpha; REV-ERBalpha; Reverbaalpha; V-erbA-related protein 1

Gene Aliases: A530070C09Rik; ear-1; EAR1; HREV; NR1D1; R75201; THRA1; THRAL

UniProt ID: (Human) P20393, (Mouse) Q3UV55

Entrez Gene ID: (Human) 9572, (Mouse) 217166

Molecular Function: C4 zinc finger nuclear receptor DNA-binding transcription factor zinc finger transcription factor gene-specific transcriptional regulator

Function(s)
negative regulation of transcription from RNA polymerase II promoter glycogen biosynthetic process transcription initiation from RNA polymerase II promoter circadian rhythm proteasomal protein catabolic process negative regulation of receptor biosynthetic process regulation of lipid metabolic process cell differentiation intracellular receptor signaling pathway circadian regulation of gene expression negative regulation of toll-like receptor 4 signaling pathway regulation of gluconeogenesis by regulation of transcription from RNA polymerase II promoter regulation of circadian rhythm steroid hormone mediated signaling pathway response to leptin regulation of fat cell differentiation negative regulation of transcription, DNA-templated positive regulation of transcription, DNA-templated circadian temperature homeostasis regulation of insulin secretion involved in cellular response to glucose stimulus regulation of type B pancreatic cell proliferation positive regulation of bile acid biosynthetic process cellular response to lipopolysaccharide regulation of cholesterol homeostasis positive regulation of cholesterol homeostasis transcription, DNA-templated regulation of transcription, DNA-templated transcription from RNA polymerase II promoter rhythmic process
Process(es)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding core promoter sequence-specific DNA binding transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding transcription corepressor binding steroid hormone receptor activity transcription corepressor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding protein binding zinc ion binding heme binding transcription regulatory region DNA binding DNA binding transcription factor activity, sequence-specific DNA binding sequence-specific DNA binding metal ion binding
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