Proteintech

NR1H4 Polyclonal Antibody

View all (12) FXR antibodies

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Questions & Answers

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NR1H4 Antibody in Western Blot (WB) — MKN-45 cells were subjected to SDS PAGE followed by western blot with 25055-1-AP ( NR1H4 Antibody) at dilution of 1:1000 incubated at room temperature for 1.5 hours.

NR1H4 Antibody in Western Blot (WB) — MKN-45 cells were subjected to SDS PAGE followed by western blot with 25055-1-AP (NR1H4 antibody) at dilution of 1:600 incubated at room temperature for 1.5 hours.

NR1H4 Antibody in Western Blot (WB) — HepG2 cells were subjected to SDS PAGE followed by western blot with 25055-1-AP (NR1H4 Antibody) at dilution of 1:100 incubated at room temperature for 1.5 hours.

Product Details

Applications

Tested Dilution

Publications

Immunofluorescence (IF)

Assay-dependent

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Western Blot (WB)

1:500-1:2000

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Product Specifications

Species Reactivity

Human

Published species

Rat

Host / Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NR1H4 Fusion Protein Ag21878

Conjugate

Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.1% sodium azide

Storage conditions

-20°C

Target Information

The Vasoactive Intestinal Polypeptide Receptor 2 (VPAC2) is a member of a family of three G-protein coupled receptors which mediate VIP (vasoactive intestinal peptide) and PACAP (pituitary adenlyate cyclase activating peptide) function in a variety of tissues. Together, the VPAC1 and VPAC2 receptors compose a subtype of the VIP receptor. Expression of the VIP and PACAP receptors has been linked to the presence of human tumors.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: Bile acid receptor; farnesoid X nuclear receptor; Farnesoid X-activated receptor; Farnesol receptor HRR-1; MGC163445; Nuclear receptor subfamily 1 group H member 4; Retinoid X receptor-interacting protein 14; RXR-interacting protein 14

Gene Aliases: BAR; FXR; HRR-1; HRR1; NR1H4; RIP14

UniProt ID: (Human) Q96RI1

Entrez Gene ID: (Human) 9971

Molecular Function: nuclear hormone receptor nucleic acid binding receptor transcription factor

negative regulation of transcription from RNA polymerase II promoter nitrogen catabolite activation of transcription from RNA polymerase II promoter regulation of carbohydrate metabolic process transcription initiation from RNA polymerase II promoter inflammatory response signal transduction Notch signaling pathway bile acid metabolic process response to glucose regulation of low-density lipoprotein particle clearance bile acid and bile salt transport intracellular receptor signaling pathway response to lipopolysaccharide toll-like receptor 4 signaling pathway regulation of urea metabolic process histone H3-R17 methylation cellular triglyceride homeostasis bile acid signaling pathway intracellular bile acid receptor signaling pathway negative regulation of apoptotic process negative regulation of I-kappaB kinase/NF-kappaB signaling steroid hormone mediated signaling pathway innate immune response positive regulation of transcription from RNA polymerase II promoter digestive tract development regulation of insulin secretion involved in cellular response to glucose stimulus regulation of bile acid biosynthetic process negative regulation of bile acid biosynthetic process cellular response to fatty acid cellular response to organonitrogen compound interleukin-17 secretion regulation of cholesterol metabolic process negative regulation of interferon-gamma secretion negative regulation of tumor necrosis factor secretion positive regulation of glutamate metabolic process positive regulation of ammonia assimilation cycle

Process(es)

RNA polymerase II distal enhancer sequence-specific DNA binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding transcriptional activator activity, RNA polymerase II transcription factor binding transcription factor activity, sequence-specific DNA binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding steroid hormone receptor activity transcription coactivator activity transcription corepressor activity RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding thyroid hormone receptor activity protein binding zinc ion binding ligand-dependent nuclear receptor binding bile acid binding bile acid receptor activity peptide binding sequence-specific DNA binding retinoid X receptor binding chenodeoxycholic acid binding