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Abnova
NR2C2 Polyclonal Antibody, MaxPab™
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Product Details
H00007182-B01P
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NR2C2 (AAH51670.1, 1 a.a. approximately 530 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Amount
50 µg
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MTSPSPRIQI ISTDSAVASP QRIQGSEPAS GPLSVFTSLN KEKIVTDQQT GQKIQIVTAV DASGSPKQQF TLTSPDGAGT GKVILASPET SSAKQLIFTT SDNLVPGRIQ IVTDSASVER LLGKTDVQRP QVVEYCVVCG DKASGRHYGA VSCEGCKGFF KRSVRKNLTY SCRSNQDCII NKHHRNRCQF CRLKKCLEMG MKMESVQSKR KPFDVQREKP SNCAASTEKI YIRKDLRSPL IATPTFVADK DGARQTGLLD PGMLVNIQQP LIREDGTVLL ATDSKAETSQ GALGTLANVV TSLANLSESL NNGDTSEIQP EDQSASEITR AFDTLAKALN TTDSSSSPSL ADGIDTSGGG SIHVISRDQS TPIIEVEGPL LSDTHVTFKL TMPSPMPEYL NVHYICESAS RLLFLSMHWA RSIPAFQALG QDCNTSLVRA CWNELFTLGL AQCAQVMSLS TILAAIVNHL QNSIQEDKLS GDRIKQVMEH IWKLQEFCNS MAKLDIDGYE YAYLKAIVLF SPGKICGGDA
Target Information
Members of the nuclear hormone receptor family, such as NR2C2, act as ligand-activated transcription factors. The proteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and a ligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Nuclear hormone receptor TR4; Nuclear receptor subfamily 2 group C member 2; Orphan nuclear receptor TAK1; Orphan nuclear receptor TR4; orphan receptor TR4; testicular nuclear receptor 4; Testicular receptor 4; TR2R1; unnamed protein product
Gene Aliases: NR2C2; TAK1; TR4
UniProt ID: (Human) P49116
Entrez Gene ID: (Human) 7182
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription factor activity, sequence-specific DNA binding
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
sequence-specific DNA binding
metal ion binding
sequence-specific double-stranded DNA binding
negative regulation of transcription from RNA polymerase II promoter
regulation of transcription, DNA-templated
spermatogenesis
nervous system development
cell differentiation
intracellular receptor signaling pathway
tumor necrosis factor-mediated signaling pathway
positive regulation of embryonic development
positive regulation of I-kappaB kinase/NF-kappaB signaling
positive regulation of transcription from RNA polymerase II promoter
positive regulation of JNK cascade
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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