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Product Details
BS-11572R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human NR2E3, amino acids 1-100.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
NR2E3, a NR2 Hepatocyte NF4-Like Receptor, has been suggested to affect cone cell proliferation in eye development. It has been shown to have a role in determining photoreceptor phenotype during human retinogenesis. In RD7 mice, a deletion in NR2E3 results in hereditary retinal dysplasia and degeneration. A homozygous missense mutation in NR2E3 has been linked to retinitis pigmentosa in Crypto-Jews of Belmonte. Two alternatively spliced isoforms have been documented. NR2E3 is expressed in the retina. ESTs have been isolated from cancerous human lung, colon, and ovary, and from normal human eye.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: MGC138414; MGC138416; Nuclear receptor subfamily 2 group E member 3; nuclear receptor subfamily 2, group E, member 3; Photoreceptor-specific nuclear receptor; Retina-specific nuclear receptor; retinal degeneration 7; RP11-295F4.5; taR-5
Gene Aliases: A930035N01Rik; ESCS; NR2E3; PNR; rd7; RNR; RP37
UniProt ID: (Human) Q9Y5X4, (Mouse) Q9QXZ7
Entrez Gene ID: (Human) 10002, (Rat) 100365683, (Mouse) 23958
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
sequence-specific DNA binding
transcription factor activity, sequence-specific DNA binding
DNA binding
metal ion binding
C4 zinc finger nuclear receptor
negative regulation of transcription from RNA polymerase II promoter
transcription from RNA polymerase II promoter
transcription initiation from RNA polymerase II promoter
signal transduction
visual perception
phototransduction
negative regulation of cell proliferation
intracellular receptor signaling pathway
eye photoreceptor cell development
steroid hormone mediated signaling pathway
positive regulation of rhodopsin gene expression
positive regulation of transcription from RNA polymerase II promoter
retina development in camera-type eye
transcription, DNA-templated
regulation of transcription, DNA-templated
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