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Invitrogen
NR4A1 Polyclonal Antibody
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Product Details
PA5-86552
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide, corresponding to amino acids 320-365 of Human Nur77/NR4A1.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Purity is > 95% by SDS-PAGE.
Target Information
NR4A1 is a member of the steroid-thyroid hormone-retinoid receptor superfamily. NGFI-B-alpha is expressed in brain, adrenal, thyroid, liver, testis, ovary, thymus, muscle, lung and prostate. Its expression is induced in response to various stress stimuli and growth factors. The encoded protein acts as a nuclear transcription factor involved in mediating apoptotic signaling in thymocytes and tumor cells, as well as having a role in signaling in the hypothalamic-pituitary axis. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Three transcript variants encoding two distinct isoforms have been identified for this NR4A1. Variant (3), also known as TRC beta, contains multiple differences compared to variant 1. The resulting isoform b contains a shorter and distinct C-terminus compared to isoform a. RXR has been shown to be a partner for NR4A1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Early response protein NAK1; growth factor-inducible nuclear protein N10; hormone receptor; immediate early gene transcription factor NGFI-B; MGC9485; nerve growth factor IB nuclear receptor variant 1; nerve growth factor induced protein I-B; Nerve growth factor-induced protein I-B; NGFI-B; Nuclear hormone receptor NUR/77; Nuclear protein N10; Nuclear receptor subfamily 4 group A member 1; nuclear receptor subfamily 4, group A, member 1; Nuclear receptor subfamily 4immunitygroup A member 1; NUR77; Orphan nuclear receptor HMR; Orphan nuclear receptor TR3; Orphan receptor tr3; ST-59; steroid receptor TR3; Testicular receptor 3; TR3 orphan receptor
Gene Aliases: Gfrp; GFRP1; Hbr-1; Hbr1; HMR; N10; NAK-1; NAK1; NGFI-B; NGFIB; NP10; NR4A1; NUR77; TIS1; TR3
UniProt ID: (Human) P22736, (Rat) P22829, (Mouse) P12813
Entrez Gene ID: (Human) 3164, (Rat) 79240, (Mouse) 15370
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
DNA binding
steroid hormone receptor activity
RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
protein binding
zinc ion binding
sequence-specific DNA binding
protein heterodimerization activity
protein homodimerization activity
transcription factor activity, sequence-specific DNA binding
metal ion binding
C4 zinc finger nuclear receptor
positive regulation of endothelial cell proliferation
cell migration involved in sprouting angiogenesis
transcription initiation from RNA polymerase II promoter
signal transduction
intracellular receptor signaling pathway
endothelial cell chemotaxis
cellular response to vascular endothelial growth factor stimulus
steroid hormone mediated signaling pathway
cellular response to fibroblast growth factor stimulus
fat cell differentiation
negative regulation of cell cycle
positive regulation of transcription from RNA polymerase II promoter
regulation of type B pancreatic cell proliferation
cellular response to corticotropin-releasing hormone stimulus
transcription, DNA-templated
transcription from RNA polymerase II promoter
apoptotic process
skeletal muscle cell differentiation
positive regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
positive regulation of transcription, DNA-templated
cellular response to organic substance
regulation of transcription, DNA-templated
response to inorganic substance
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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