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Proteintech
NSDHL Polyclonal Antibody
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Product Details
15111-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
NSDHL Fusion Protein Ag7097 (1-303 aa encoded by BC000245)
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Amount
58.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MEPAVSEPM RDQVARTHLT EDTPKVNADI EKVNQNQAKR CTVIGGSGFL GQHMVEQLLA RGYAVNVFDI QQGFDNPQVR FFLGDLCSRQ DLYPALKGVN TVFHCASPPP SSNNKELFYR VNYIGTKNVI ETCKEAGVQK LILTSSASVI FEGVDIKNGT EDLPYAMKPI DYYTETKILQ ERAVLGANDP EKNFLTTAIR PHGIFGPRDP QLVPILIEAA RNGKMKFVIG NGKNLVDFTF VENVVHGHIL AAEQLSRDST LGGKAFHITN DEPIPFWTFL SRILTGLNYE APKYHIPYWV AYYL (1-303 aa encoded by BC000245)
Target Information
The protein encoded by this gene is localized in the endoplasmic reticulum and is involved in cholesterol biosynthesis. Mutations in this gene are associated with CHILD syndrome, which is a X-linked dominant disorder of lipid metabolism with disturbed cholesterol biosynthesis, and typically lethal in males. Alternatively spliced transcript variants with differing 5' UTR have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 3-beta-hydroxysteroid dehydrogenase; 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating); bare patches; epididymis secretory sperm binding protein; H105e3; NAD(P) dependent steroid dehydrogenase-like protein transcript; NAD(P)-dependent steroid dehydrogenase-like protein; Protein H105e3; short chain dehydrogenase/reductase family 31E, member 1; Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating; striated
Gene Aliases: AI747449; Bpa; H105E3; NSDHL; SDR31E1; Str; XAP104
UniProt ID: (Human) Q15738, (Mouse) Q9R1J0, (Rat) Q5PPL3
Entrez Gene ID: (Human) 50814, (Mouse) 18194, (Rat) 309262
C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity
3-beta-hydroxy-delta5-steroid dehydrogenase activity
protein binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
3-beta-hydroxysteroid dehydrogenase (NAD+)/C4-decarboxylase activity
sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity
molecular_function
dehydratase
hair follicle development
lipid metabolic process
steroid biosynthetic process
cholesterol biosynthetic process
smoothened signaling pathway
steroid metabolic process
cholesterol metabolic process
sterol biosynthetic process
labyrinthine layer blood vessel development
oxidation-reduction process
biological_process
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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