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Invitrogen
NTF3 Polyclonal Antibody
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FIGURE: 1 / 2
NTF3 Antibody (PA1-18385) in WB
eLife 2015 -
Figure 6. Expression of the neurotrophic factor neurotrophin 3 in visually impaired mutants. ( A ) Relative expression levels of bdnf , ntf3, ntf4, ntf7 , and ngf in 4 dpf old wild-type and kif5aa mutant embryos. ntf3 is upregulated to 160% of wild-type expression levels (p < 0.05) while all other neurotrophic factors show the same expression levels between wild-type and mutant embryos. ( B ) Transversal se... View More
Product Details
PA1-18385
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken,
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to residues Y(139) A E H K S H R G E Y(149) of human, mouse and rat NT3.
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Reconstitute in 20 µL of sterile water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20 °C for a higher stability, and at 4 °C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.
Target Information
The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: HDNF; Nerve growth factor 2; Neurotrophic factor; Neurotrophin-3; neurotrophin-3 (HDNF/NT-3); NGF-2; NT-3
Gene Aliases: HDNF; neurotrophin-3; NGF-2; NGF2; NT-3; NT3; Ntf-3; NTF3
UniProt ID: (Chicken) P25433, (Human) P20783, (Rat) P18280
Entrez Gene ID: (Chicken) 428099, (Human) 4908, (Rat) 81737
transmembrane receptor protein tyrosine kinase signaling pathway
peripheral nervous system development
memory
nerve development
positive regulation of peptidyl-serine phosphorylation
nerve growth factor signaling pathway
negative regulation of neuron apoptotic process
regulation of neuron differentiation
neuron projection morphogenesis
modulation of synaptic transmission
activation of MAPK activity
positive regulation of receptor internalization
signal transduction
cell-cell signaling
nervous system development
positive regulation of cell proliferation
positive regulation of cell migration
activation of protein kinase B activity
myelination
regulation of apoptotic process
positive regulation of glial cell differentiation
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of peptidyl-tyrosine phosphorylation
positive chemotaxis
induction of positive chemotaxis
activation of GTPase activity
positive regulation of actin cytoskeleton reorganization
neuromuscular synaptic transmission
glial cell fate determination
axon guidance
brain development
epidermis development
mechanoreceptor differentiation
regulation of neuron apoptotic process
positive regulation of transcription from RNA polymerase II promoter
enteric nervous system development
neuron development
generation of neurons
smooth muscle cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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