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Invitrogen
NTN3 Polyclonal Antibody
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Product Details
PA5-47110
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Chicken
Host/Isotype
Goat
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Mouse myeloma cell line NS0-derived recombinant chicken Netrin-2 Ala16-Pro581
Conjugate
Form
Lyophilized
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS with 5% trehalose
Contains
No Preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2606313
Product Specific Information
In direct ELISAs, approximately 10% cross-reactivity with recombinant chicken Netrin-1 is observed and less than 1% cross-reactivity with recombinant human Netrin-4, recombinant mouse (rm) Netrin-G1a and rmNetrin-G2a is observed.
Reconstitute at 0.2 mg/mL in sterile PBS.
Endoxin level is <0.10 EU per 1 µg of the antibody by the LAL method.
Target Information
Netrin-3 (NTN3) is a gene located on chromosome 16q22.1, encoding a protein that belongs to the netrin family of secreted molecules crucial for axon guidance and cell signaling in nervous system development. NTN3 is primarily expressed in the central nervous system, where it functions as a guidance cue for developing neurons, influencing processes such as axon attraction or repulsion and the establishment of neural networks. The protein interacts with specific receptors on neuronal growth cones to mediate directional movement and synapse formation. Beyond its role in neural development, NTN3 is involved in tissue morphogenesis and cellular migration in other physiological contexts. Aberrant expression or mutations in NTN3 can lead to developmental disorders and neurodegenerative conditions due to impaired neural pathway formation. Research into NTN3 continues to explore its therapeutic potential for enhancing neural repair and regeneration in pathological states.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
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