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Abnova

NTRK3 Polyclonal Antibody, MaxPab™

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NTRK3 Polyclonal Antibody, MaxPab™

Product Details

H00004916-D01P

Applications
Tested Dilution
Publications

Western Blot (WB)

1:1,000
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

NTRK3 (NP_001007157.1, 1 a.a. approximately 612 a.a) full-length human protein.
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5-1 mg/mL

Amount

100 µg

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Product may be used with Western Blot (Transfected lysate).

The Isotype of this product is composed of an IgG Mixture.

Immunogen sequence: MDVSLCPAKC SFWRIFLLGS VWLDYVGSVL ACPANCVCSK TEINCRRPDD GNLFPLLEGQ DSGNSNGNAS INITDISRNI TSIHIENWRS LHTLNAVDME LYTGLQKLTI KNSGLRSIQP RAFAKNPHLR YINLSSNRLT TLSWQLFQTL SLRELQLEQN FFNCSCDIRW MQLWQEQGEA KLNSQNLYCI NADGSQLPLF RMNISQCDLP EISVSHVNLT VREGDNAVIT CNGSGSPLPD VDWIVTGLQS INTHQTNLNW TNVHAINLTL VNVTSEDNGF TLTCIAENVV GMSNASVALT VYYPPRVVSL EEPELRLEHC IEFVVRGNPP PTLHWLHNGQ PLRESKIIHV EYYQEGEISE GCLLFNKPTH YNNGNYTLIA KNPLGTANQT INGHFLKEPF PESTDNFILF DEVSPTPPIT VTHKPEEDTF GVSIAVGLAA FACVLLVVLF VMINKYGRRS KFGMKGPVAV ISGEEDSASP LHHINHGITT PSSLDAGPDT VVIGMTRIPV IENPQYFRQG HNCHKPDTWV FSNIDNHGIL NLKDNRDHLV PSTHYIYEEP EVQSGEVSYP RSHGFREIML NPISLPGHSK PLNHGIYVED VNVYFSKGRH GF

Target Information

NTRK3 (TRKC) belongs to the neurotrophic factor family of related polypeptides central to the development and maintenance of the mammalian nervous system. Known substrates for the TRK receptors are SHC, PI-3 kinase, and PLCG1. The different isoforms do not have identical signaling properties. The protein is widely expressed, mainly in the nervous tissue. The isoform B is expressed in a relatively large amount in the adult brain comparatively to fetal brain. TRKC is subject to ligand-mediated auto-phosphorylation. The protein structure contains 2 immunoglobulin-like C2-type domains and 2 leucine-rich (LRR) repeats.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ETS related protein-neurotrophic receptor tyrosine kinase fusion protein; ETV6-NTRK3 fusion; GP145-TrkC; Neurotrophic tyrosine kinase receptor type 3; neurotrophic tyrosine kinase, receptor, type 3; NT-3 growth factor receptor; NTRK3; splice variant; TEL-TrkC fusion protein; Trk-C; trkC; TrkC tyrosine kinase; tyrosine kinase receptor C; unnamed protein product

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Gene Aliases: gp145(trkC); GP145-TrkC; NTRK3; TRKC

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UniProt ID: (Human) Q16288

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Entrez Gene ID: (Human) 4916

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Function(s)
nucleotide binding p53 binding protein kinase activity protein tyrosine kinase activity transmembrane receptor protein tyrosine kinase activity GPI-linked ephrin receptor activity neurotrophin receptor activity protein binding ATP binding kinase activity transferase activity neurotrophin binding
Process(es)
neuron migration cell communication transmembrane receptor protein tyrosine kinase signaling pathway nervous system development heart development circadian rhythm positive regulation of cell proliferation positive regulation of gene expression positive regulation of neuron projection development neuronal action potential propagation myelination in peripheral nervous system cell differentiation positive regulation of cell migration neurotrophin signaling pathway mechanoreceptor differentiation positive regulation of apoptotic process positive regulation of MAPK cascade response to ethanol ephrin receptor signaling pathway animal organ development neuron fate specification axon extension involved in regeneration response to axon injury positive regulation of axon extension involved in regeneration negative regulation of astrocyte differentiation system development positive regulation of positive chemotaxis response to corticosterone positive regulation of protein kinase B signaling positive regulation of synapse assembly lens fiber cell differentiation cellular response to retinoic acid cochlea development postsynaptic density assembly regulation of presynapse assembly cellular response to nerve growth factor stimulus regulation of neural precursor cell proliferation
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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