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Product Details
PA5-79767
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
0.1-0.5 µg/mL | - |
Immunohistochemistry (Paraffin) (IHC (P)) |
0.5-1 µg/mL | - |
ELISA (ELISA) |
0.1-0.5 µg/mL | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Mouse, Rat |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
E. coli-derived mouse Nucleobindin 2 recombinant protein (Position: V25-L106). |
Conjugate |
Unconjugated |
Form |
Lyophilized |
Concentration |
500 µg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS with 5mg BSA |
Contains |
0.05mg sodium azide |
Storage conditions |
-20°C |
RRID |
AB_2746882 |
Product Specific Information
Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 µg/mL.
Target Information
NUCB2 was initially identified as calcium-binding protein EF hand motif-containing protein that could bind with Necdin, a growth suppressor expressed primarily in postmitotic neurons. NUC2 is a secreted protein that is cleaved into three major peptide products, Nesfatin-1, Nesfatin-2, and Nesfatin-3, of which Nesfatin-1 has been found to cause the suppression of food intake in a leptin-independent manner. Other studies have suggested that NUCB2/Nesfatin-1 may also play roles in energy homeostasis and closely related neuroendocrine functions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: DNA-binding protein NEFA; Nesfatin-1; Nucleobindin-2; Nucleobindin-2/Nesfatin-1; prepronefastin; Prepronesfatin
Gene Aliases: AI607786; Calnuc; Nefa; Nesfatin-1; Nucb2; p54
UniProt ID: (Mouse) P81117, (Rat) Q9JI85
Entrez Gene ID: (Mouse) 53322, (Rat) 59295
Molecular Function:
calmodulin-related
cellular calcium ion homeostasis
negative regulation of cAMP biosynthetic process
negative regulation of appetite
negative regulation of fat cell differentiation
positive regulation of fatty acid oxidation
negative regulation of insulin receptor signaling pathway
negative regulation of glucagon secretion
insulin metabolic process
positive regulation of testosterone secretion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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