Immunogen sequence: EKENYHYVTI LMKGEVDVTH DSEPKNVEPE KNESWEWVPW EELPPLDQLF WGLRCLKEQG YDPFKEDLNH LVGYKGNHL
Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 90%.
Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear. May have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 8-dihydro-8-oxoguanine triphosphatase NUDT15; 8-oxo-dGTPase NUDT15; A730068G11Rik; MTH2; MutT homolog 2; Nucleoside diphosphate-linked moiety X motif 15; Nucleoside diphosphate-linked to another moiety X hydrolase 15; Nucleotide triphosphate diphosphatase NUDT15; nudix (nucleoside diphosphate linked moiety X)-type motif 15; Nudix hydrolase 15; Nudix motif 15; nudix-type motif 15; probable 7; probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15; RP11-90M2.1
Gene Aliases: MTH2; NUDT15; NUDT15D
UniProt ID: (Human) Q9NV35
Entrez Gene ID: (Human) 55270