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A suggested positive control is mouse lung tissue lysate.
PA5-21143 can be used with blocking peptide PEP-1257.
Protein NUMB homolog is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells. Recent studies have revealed that NUMB functions in clathrin-dependent endocytosis by binding to the AP-2 complex. NUMB is also expressed in postmitotic neurons and plays a role in axonal growth. Neural cells expressing Numb isoforms with short phosphotyrosine-binding (SPTB) domain undergo extensive neurite outgrowth, an effect that can be blocked by voltage-gated Ca2+ channel (VGCC) inhibitor or by Ca2+ chelator.
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Protein Aliases: h-Numb; m-Nb; m-numb; mnb; numb gene homolog; numb homolog; Protein numb homolog; Protein S171
Gene Aliases: c14_5527; C14orf41; Nb; NUMB; S171
Molecular Function: scaffold/adaptor protein