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Proteintech
Nesprin 3 Polyclonal Antibody
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Product Details
27132-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Nesprin 3 Fusion Protein Ag26002 (1-300 aa encoded by BC146604)
Conjugate
Form
Liquid
Concentration
0.77 mg/mL
Amount
115.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MTQQPQDDF DRSVEDAQAW MKAVQDQLQV NDNTQGPRAA LEARLWETEK ICQLEPEGRV RVDLVLRMAE ALLACCPGDQ KPGILARLKD IKAQWEETVT YMTHCHSRIE WVWLHWSEYL LARDEFYRWF QKMMVTLEPH IELQLGLKEK QWQLSHAQVL LHNVDNQAVL LDRLLEEAAS LFNRIGDPSV DEDAQKRMKA EYDAVKAKAQ KRVDLLEQVA REHEEYQAGV DEFQLWLKAV VEKVNGCLGR NCKLPITQRL STLQDIAKDF PRGEESLETL EEQSAGVIRN TSPLGAEKIT G (1-300 aa encoded by BC146604)
Target Information
As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells. [UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C14orf139; KASH domain-containing protein 3; KASH3; long intergenic non-protein coding RNA 341; Nesprin-3; Nuclear envelope spectrin repeat protein 3; uncharacterized protein C14orf113; unnamed protein product
Gene Aliases: C14orf139; C14orf49; KASH3; LINC00341; NCRNA00341; Nesp3; nesprin-3; NET53; RGD1304563; SYNE3
UniProt ID: (Human) Q6ZMZ3, (Mouse) Q4FZC9
Entrez Gene ID: (Human) 161176, (Rat) 299356, (Mouse) 212073
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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