Bioss

Neurokinin 1 Receptor Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Tech Support
Datasheet
Protocols
Questions & Answers
Tech Support
Neurokinin 1 Receptor Polyclonal Antibody

Product Details

BS-0064R

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300
-

Immunohistochemistry (Paraffin) (IHC (P))

1:200
-

Immunohistochemistry (Frozen) (IHC (F))

1:100-1:500
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

ELISA (ELISA)

1:500-1:1,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

KLH conjugated synthetic peptide derived from human Neurokinin 1 Receptor, amino acids 2-50.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

0.01M TBS, pH 7.4, with 1% BSA, 50% glycerol

Contains

0.02% ProClin 300

Storage conditions

-20°C

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

Tachykinin Receptor 1, a member of the Tachykinin Receptor subfamily, is involved in the mediation of phosphatidylinositol metabolism by the tachykinin substance P, also referred to as neurokinin 1. It is associated with the management of depression, anxiety, and stress. It is also involved in regulating behavioral responses, neuronal survival, and cardiovascular and respiratory functions. The tachykinin receptor 1 is implicated in the progression of rheumatoid arthritis and osteoarthritis. Two variants of the tachykinin receptor 1 are produced by alternative splicing. Tachykinin receptor 1 has been reported primarily in brain, and in blood lymphocytes, nose, small intestine, and stomach. ESTs have been isolated from brain and spleen libraries.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: neurokinin 1 receptor; neurokinin receptor 1; NK-1 receptor; NK-1R; Nk1 receptor; SPR; substance P receptor; Substance-P receptor; Tachykinin receptor 1; tachykinin receptor 1 (substance P receptor; neurokinin-1 receptor)

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Gene Aliases: NK1R; NKIR; SPR; TAC1R; TACR1

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UniProt ID: (Human) P25103, (Mouse) P30548, (Rat) P14600

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Entrez Gene ID: (Human) 6869, (Mouse) 21336, (Rat) 24807

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Function(s)
tachykinin receptor activity protein binding substance P receptor activity signal transducer activity G-protein coupled receptor activity G-protein coupled receptor
Process(es)
aggressive behavior acute inflammatory response positive regulation of leukocyte migration angiotensin-mediated drinking behavior inflammatory response cell surface receptor signaling pathway phospholipase C-activating G-protein coupled receptor signaling pathway positive regulation of cytosolic calcium ion concentration tachykinin receptor signaling pathway chemical synaptic transmission long-term memory associative learning response to heat detection of abiotic stimulus response to ozone positive regulation of epithelial cell migration response to auditory stimulus regulation of smooth muscle cell migration sensory perception of pain positive regulation of synaptic transmission, cholinergic positive regulation of synaptic transmission, GABAergic response to estradiol response to progesterone response to nicotine operant conditioning positive regulation of renal sodium excretion sperm ejaculation eating behavior positive regulation of vascular permeability response to morphine response to ethanol positive regulation of action potential positive regulation of blood pressure positive regulation of ossification positive regulation of vasoconstriction positive regulation of smooth muscle contraction positive regulation of saliva secretion positive regulation of hormone secretion behavioral response to pain regulation of smooth muscle cell proliferation positive regulation of lymphocyte proliferation positive regulation of epithelial cell proliferation positive regulation of stress fiber assembly response to electrical stimulus smooth muscle contraction involved in micturition positive regulation of uterine smooth muscle contraction signal transduction G-protein coupled receptor signaling pathway neuropeptide signaling pathway learning or memory regulation of blood pressure response to hormone response to organic cyclic compound response to pain
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