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Nicotinic acetylcholine R alpha-10 Polyclonal Antibody
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Product Details
OSC00191W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from c-terminal region of human Neuronal acetylcholine receptor subunit alpha-10 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The antigen shares 85% identity with mouse and rat sequences.
Specificity of this antibody: CHRNA10.
Target Information
Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: acetylcholine receptor; acetylcholine receptor, nicotinic, alpha 10 (neuronal); cholinergic receptor; cholinergic receptor, nicotinic alpha 10; cholinergic receptor, nicotinic, alpha 10 (neuronal); cholinergic receptor, nicotinic, alpha polypeptide 10; CHRNA10; NACHR alpha-10; Neuronal acetylcholine receptor subunit alpha-10; Nicotinic acetylcholine receptor subunit alpha-10
Gene Aliases: CHRNA10; NACHRA10
UniProt ID: (Human) Q9GZZ6
Entrez Gene ID: (Human) 57053
transmembrane signaling receptor activity
receptor binding
ion channel activity
extracellular ligand-gated ion channel activity
excitatory extracellular ligand-gated ion channel activity
calcium channel activity
acetylcholine-gated cation channel activity
serotonin-gated cation channel activity
transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
ion transport
calcium ion transport
positive regulation of cytosolic calcium ion concentration
serotonin receptor signaling pathway
chemical synaptic transmission
synaptic transmission, cholinergic
response to auditory stimulus
ion transmembrane transport
regulation of cell proliferation
regulation of membrane potential
inner ear morphogenesis
detection of mechanical stimulus involved in sensory perception of sound
membrane depolarization
regulation of postsynaptic membrane potential
excitatory postsynaptic potential
regulation of biological quality
negative regulation of ERK1 and ERK2 cascade
calcium ion transmembrane transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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