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The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD.The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD (Zhang et al., 2003 [PubMed 12574164]).[supplied by OMIM]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
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Protein Aliases: deamido-NAD(+) diphosphorylase; deamido-NAD(+) pyrophosphorylase; EC 2.7.7.1; EC 2.7.7.18; NAD(+) diphosphorylase; NAD(+) pyrophosphorylase; NaMN adenylyltransferase 1; nicotinamide mononucleotide adenylyl transferase; nicotinamide mononucleotide adenylyl transferase 1; Nicotinamide mononucleotide adenylyltransferase 1; Nicotinamide-nucleotide adenylyltransferase 1; nicotinamide/nicotinate mononucleotide adenylyltransferase 1; Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1; Nicotinate-nucleotide adenylyltransferase 1; NMN adenylyltransferase 1; NMN/NaMN adenylyltransferase 1; NMNATPNAT1; PNAT-1; pyridine nucleotide adenylyltransferase 1
Gene Aliases: 2610529L11Rik; 5730441G13Rik; D4Cole1e; LCA9; NMNAT; NMNAT1; PNAT1
UniProt ID: (Human) Q9HAN9, (Mouse) Q9EPA7
Entrez Gene ID: (Human) 64802, (Rat) 298653, (Mouse) 66454
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