|Tested species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues P(156) V L Y A W N D L G S R F W P(170) of the human Noggin (NOG) protein.|
|Contains||0.02% sodium azide|
|Storage Conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
|Tested Applications||Dilution *|
|Western Blot (WB)||1:1000|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
PA1-4521 detects Noggin (NOG) in human samples. The immunizing peptide sequence is 100% conserved in rat and mouse.
PA1-4521 has been successfully used in Western blot procedures. This antibody is specific for the ~32 kDa protein representing Noggin (NOG) .
PA1-4521 immunogen is a synthetic peptide corresponding to residues 156-170 of the human Noggin (NOG) protein.
Noggin is involved in numerous developmental processes, such as neural tube fusion and joint formation. The morphogenesis of organs is initiated by a downgrowth from a layer of epithelial stem cells. This process is achieved through the receipt of signals from 1) a WNT protein (WNT3A) to stabilize beta-catenin; and 2) Noggin, which is a bone morphogenetic protein inhibitor. Noggin mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) have been identified, which have multiple joint fusion as their principal defect.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.