|Tested species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues 64-74 of human Nogo-B receptor (NgBR).|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage Conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
|Tested Applications||Dilution *|
|Western Blot (WB)||1-3 µg/ml|
* Suggested working dilutions are given as a guide only. It is recommended that the user titrate the product for use in their own experiment using appropriate negative and positive controls.
NgBR, also known as Nogo-B receptor, is a 293 amino acid rich member of the UPP synthetase family. Though the extact fundtion of NgBR is still not clear, reports suggest that this membrane protein acts as a specific receptor for the N-terminus of Nogo-B, a neural and cardiovascular regulator. It has similarity with UPP synthetase proteins which suggests that it may act as a scaffold for the binding of isoprenyl lipids and/or prenylated proteins but has no lipid transferase activity. NgBR colocalizes with Nogo-B during VEGF and wound healing angiogenesis and is thus able to regulate vascular remodeling and angiogenesis. Nogo-B and NgBR mediate chemotaxis in HUVECs and induced tube formation in three-dimensional cultures.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.