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Bethyl Laboratories
Notch2 Polyclonal Antibody
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Product Details
A302-084A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 2421 and 2471 of human neurogenic locus notch homolog protein 2.
Conjugate
Form
Liquid
Concentration
0.20 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
TBS, pH 7.0 to 8.0, with 0.1% BSA
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
Neurogenic locus notch homolog protein 2 (NOTCH2) is a highly conserved Notch signaling pathway protein. NOTCH2 is a type 1 transmembrane protein with an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. NOTCH2 functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Defects in NOTCH2 are the cause of Alagille syndrome type 2 (ALGS2). Alagille syndrome is an autosomal dominant multisystem disorder defined clinically by hepatic bile duct paucity and cholestasis in association with cardiac, skeletal, and ophthalmologic manifestations. There are characteristic facial features and less frequent clinical involvement of the renal and vascular systems.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Neurogenic locus notch homolog protein 2; Notch 2; Notch homolog 2
Gene Aliases: AGS2; HJCYS; hN2; NOTCH2
UniProt ID: (Human) Q04721
Entrez Gene ID: (Human) 4853
cell fate determination
marginal zone B cell differentiation
pulmonary valve morphogenesis
regulation of transcription, DNA-templated
transcription initiation from RNA polymerase II promoter
apoptotic process
cell cycle arrest
Notch signaling pathway
multicellular organism development
nervous system development
negative regulation of cell proliferation
organ morphogenesis
cell growth
stem cell population maintenance
hemopoiesis
intracellular receptor signaling pathway
tissue regeneration
negative regulation of apoptotic process
positive regulation of Ras protein signal transduction
bone remodeling
regulation of developmental process
atrial septum morphogenesis
Notch signaling involved in heart development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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