Rockland

Nrf2 Polyclonal Antibody

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Product Details

600-401-GT6

Applications
Tested Dilution
Publications

Western Blot (WB)

1.0 µg/mL
-

ELISA (ELISA)

5 µg/mL
-
Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Anti-NRF-2 antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding near the c-term region.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Affinity chromatography

Storage buffer

0.02M potassium phosphate, pH 7.2, with 0.15M NaCl

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

This affinity-purified antibody is directed against mouse Nrf2 protein. A BLAST analysis was used to suggest cross reactivity with Nrf2 proteins from human, mouse, rat and bovine based on 100% homology with the immunizing sequence. Reactivity against homologues from other sources is not known.

Target Information

Nfr1 (also designated TCF11), Nrf2 and Nfr3 are bZIP transcription factors that heterodimer with Maf proteins to bind MARE (Maf recognition elements) sequences. Nrf2 is widely expressed and is thought to translocate to the nucleus after treatment with xenobiotics and antioxidants, which stimulate its release from a repressor protein Keap1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: E4TF1-60; E4TF1A; NF-E2-related factor 2; NFE2-related factor 2; NFT2; NRF2A; Nuclear factor erythroid 2-related factor 2; nuclear factor erythroid-derived 2-like 2; nuclear factor, erythroid 2-like 2; Nuclear factor, erythroid derived 2, like 2

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Gene Aliases: AI194320; HEBP1; NFE2L2; NRF2

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UniProt ID: (Human) Q16236, (Mouse) Q60795

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Entrez Gene ID: (Human) 4780, (Mouse) 18024

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Function(s)
transcription regulatory region sequence-specific DNA binding RNA polymerase II distal enhancer sequence-specific DNA binding RNA polymerase II activating transcription factor binding transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding transcription cofactor binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein domain specific binding transcription regulatory region DNA binding sequence-specific DNA binding protein heterodimerization activity basic leucine zipper transcription factor
Process(es)
transcription from RNA polymerase II promoter inflammatory response proteasomal ubiquitin-independent protein catabolic process positive regulation of gene expression protein ubiquitination positive regulation of blood coagulation endoplasmic reticulum unfolded protein response cellular response to oxidative stress cellular response to drug positive regulation of transcription from RNA polymerase II promoter in response to stress positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress PERK-mediated unfolded protein response cellular response to glucose starvation proteasome-mediated ubiquitin-dependent protein catabolic process cell redox homeostasis positive regulation of transcription from RNA polymerase II promoter regulation of embryonic development positive regulation of glucose import cellular response to hydrogen peroxide cellular response to tumor necrosis factor cellular response to fluid shear stress cellular response to laminar fluid shear stress negative regulation of hematopoietic stem cell differentiation negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway positive regulation of ER-associated ubiquitin-dependent protein catabolic process negative regulation of hydrogen peroxide-induced cell death positive regulation of glutathione biosynthetic process regulation of removal of superoxide radicals negative regulation of endothelial cell apoptotic process positive regulation of reactive oxygen species metabolic process transcription, DNA-templated regulation of transcription, DNA-templated response to endoplasmic reticulum stress positive regulation of transcription, DNA-templated negative regulation of cell death
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