Suggested positive control: antigen standard for NR4A2 (transient overexpression lysate).
The Nurr1 gene encodes a member of the steroid-thyroid hormone- retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson's. Nurr1 is a stem cell marker and cooperates with PITX3 to promote terminal maturation of murine and human embryonic stem cell cultures to a midbrain dopamine neuron phenotype. In addition, Nurr1 is involved in the regulation of corticotropin-releasing hormone (CRH), which may be linked to and associated with rheumatoid arthritis.
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Protein Aliases: human homolog of; HZF-3; Immediate-early response protein NOT; intermediate-early receptor protein; NGFI-B/nur77 beta-type transcription factor homolog; NOT; Nuclear orphan receptor HZF-3; nuclear receptor related 1; Nuclear receptor subfamily 4 group A member 2; nuclear receptor subfamily 4 group A member 2 variant TINUR; nuclear receptor subfamily 4 group A member 2 variant NURR1a; nuclear receptor subfamily 4 group A member 2 variant NURR1b; nuclear receptor subfamily 4 group A member 2 variant NURR1c; nuclear receptor subfamily 4 group A member 2 variant NURR2c; nuclear receptor subfamily 4, group A, member 2; nur related protein 1; nur related protein-1; nur related protein-1, human homolog of; NUR-related factor 1; NURR1; orphan nuclear receptor NR4A2; Orphan nuclear receptor NURR1; Regenerating liver nuclear receptor 1; RNR-1; RNR1; SL-322; T-cell nuclear receptor NOT; TINUR; transcriptionally inducible nuclear receptor related 1; Transcriptionally-inducible nuclear receptor
Gene Aliases: HZF-3; NOT; NR4A2; NURR1; RNR1; TINUR