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Proteintech
OAS1 Polyclonal Antibody
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Product Details
14955-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Pig
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
OAS1 Fusion Protein Ag6793 (1-351 aa encoded by BC000562)
Conjugate
Form
Liquid
Concentration
0.16 mg/mL
Amount
24 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MMDLRNTPA KSLDKFIEDY LLPDTCFRMQ INHAIDIICG FLKERCFRGS SYPVCVSKVV KGGSSGKGTT LRGRSDADLV VFLSPLTTFQ DQLNRRGEFI QEIRRQLEAC QRERAFSVKF EVQAPRWGNP RALSFVLSSL QLGEGVEFDV LPAFDALGQL TGSYKPNPQI YVKLIEECTD LQKEGEFSTC FTELQRDFLK QRPTKLKSLI RLVKHWYQNC KKKLGKLPPQ YALELLTVYA WERGSMKTHF NTAQGFRTVL ELVINYQQLC IYWTKYYDFK NPIIEKYLRR QLTKPRPVIL DPADPTGNLG GGDPKGWRQL AQEAEAWLNY PCFKNWDGSP VSSWILLVRP PA (1-351 aa encoded by BC000562)
Target Information
OAS1 is an interferon inducible protein that may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. It binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. This protein is associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: (2-5')oligo(A) synthase 1; (2-5')oligo(A) synthase 1A; (2-5')oligo(A) synthetase 1; (2-5')oligo(A) synthetase 1A; 2',5'-oligo A synthetase 1; 2',5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5' oligoadenylate synthetase 1G; 2'-5'-oligoadenylate synthase 1; 2'-5'-oligoadenylate synthase 1 isoform p42; 2'-5'-oligoadenylate synthase 1A; 2'-5'-oligoadenylate synthetase 1; 2'-5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5'-oligoisoadenylate synthetase 1; 2-5A synthase 1; 2-5A synthase 1A; 2-5A synthetase 1; 2-5A synthetase 1A; 25 oligoadenylate synthetase; E16 (2'-5') oligo A synthetase; E18/E16; IFI 4; IFI4; OAS 1; p42 OAS; p46/p42 OAS; short exon 3; targeted by nonsense-mediated decay (NMD) due to premature termination codon in exon 4; unnamed protein product
Gene Aliases: E18/E16; IFI-4; IMD100; L3; OAS1; Oas1a; Oas1g; OIAS; Oias1; OIASI
UniProt ID: (Human) P00973, (Rat) Q05961, (Mouse) P11928
Entrez Gene ID: (Human) 4938, (Rat) 192281, (Mouse) 246730
immune system process
glucose metabolic process
response to virus
positive regulation of interferon-beta production
positive regulation of tumor necrosis factor production
toll-like receptor 3 signaling pathway
toll-like receptor 4 signaling pathway
cellular response to interferon-alpha
cellular response to interferon-beta
glucose homeostasis
defense response to bacterium
surfactant homeostasis
negative regulation of viral genome replication
innate immune response
protein oligomerization
defense response to virus
type I interferon signaling pathway
negative regulation of type I interferon-mediated signaling pathway
regulation of ribonuclease activity
interleukin-27-mediated signaling pathway
cellular response to exogenous dsRNA
positive regulation of monocyte chemotactic protein-1 production
negative regulation of IP-10 production
defense response to other organism
cellular response to virus
antiviral innate immune response
positive regulation of cellular respiration
negative regulation of chemokine (C-X-C motif) ligand 2 production
purine nucleotide biosynthetic process
immune response
metabolic process
negative regulation of viral process
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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