Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:500-1:2,000 | View 2 publications 2 publications |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:100-1:400 | - |
Immunocytochemistry (ICC/IF) |
1:50-1:500 | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
OAS1 Fusion Protein Ag6793 (1-351 aa encoded by BC000562) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.16 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MMDLRNTPA KSLDKFIEDY LLPDTCFRMQ INHAIDIICG FLKERCFRGS SYPVCVSKVV KGGSSGKGTT LRGRSDADLV VFLSPLTTFQ DQLNRRGEFI QEIRRQLEAC QRERAFSVKF EVQAPRWGNP RALSFVLSSL QLGEGVEFDV LPAFDALGQL TGSYKPNPQI YVKLIEECTD LQKEGEFSTC FTELQRDFLK QRPTKLKSLI RLVKHWYQNC KKKLGKLPPQ YALELLTVYA WERGSMKTHF NTAQGFRTVL ELVINYQQLC IYWTKYYDFK NPIIEKYLRR QLTKPRPVIL DPADPTGNLG GGDPKGWRQL AQEAEAWLNY PCFKNWDGSP VSSWILLVRP PA (1-351 aa encoded by BC000562)
OAS1 is an interferon inducible protein that may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. It binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. This protein is associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: (2-5')oligo(A) synthase 1; (2-5')oligo(A) synthase 1A; (2-5')oligo(A) synthetase 1; (2-5')oligo(A) synthetase 1A; 2',5'-oligo A synthetase 1; 2',5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5' oligoadenylate synthetase 1G; 2'-5'-oligoadenylate synthase 1; 2'-5'-oligoadenylate synthase 1A; 2'-5'-oligoadenylate synthetase 1; 2'-5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5'-oligoisoadenylate synthetase 1; 2-5A synthase 1; 2-5A synthase 1A; 2-5A synthetase 1; 2-5A synthetase 1A; 25 oligoadenylate synthetase; E16 (2'-5') oligo A synthetase; E18/E16; IFI 4; IFI4; OAS 1; p42 OAS; p46/p42 OAS
Gene Aliases: E18/E16; IFI-4; L3; OAS1; Oas1a; Oas1g; OIAS; Oias1; OIASI
UniProt ID: (Human) P00973, (Rat) Q05961, (Mouse) P11928
Entrez Gene ID: (Human) 4938, (Rat) 192281, (Mouse) 246730
Molecular Function:
nucleotidyltransferase
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