Proteintech

OAS1 Polyclonal Antibody

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OAS1 Antibody in Immunocytochemistry (ICC/IF) — Immunofluorescent analysis of ( 10% Formaldehyde ) fixed HeLa cells using 14955-1-AP (OAS1 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

OAS1 Antibody in Immunohistochemistry (Paraffin) (IHC (P)) — Immunohistochemistry of paraffin-embedded human liver tissue slide using 14955-1-AP ( OAS1 Antibody) at dilution of 1:200 (under 40x lens).

OAS1 Antibody in Western Blot (WB) — Mouse brain tissue were subjected to SDS PAGE followed by western blot with 14955-1-AP (OAS1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

Product Details

14955-1-AP

Applications	Tested Dilution	Publications
Western Blot (WB)	1:500-1:2,000	View 2 publications 2 publications
Immunohistochemistry (Paraffin) (IHC (P))	1:100-1:400	-
Immunocytochemistry (ICC/IF)	1:50-1:500	-

Product Specifications
Species Reactivity	Human, Mouse, Rat
Published species	Human
Host/Isotype	Rabbit / IgG
Class	Polyclonal
Type	Antibody
Immunogen	OAS1 Fusion Protein Ag6793 (1-351 aa encoded by BC000562) View immunogen
Conjugate	Unconjugated
Form	Liquid
Concentration	0.16 mg/mL
Purification	Antigen affinity chromatography
Storage buffer	PBS, pH 7.3, with 50% glycerol
Contains	0.02% sodium azide
Storage conditions	-20°C

Product Specific Information

Immunogen sequence: MMDLRNTPA KSLDKFIEDY LLPDTCFRMQ INHAIDIICG FLKERCFRGS SYPVCVSKVV KGGSSGKGTT LRGRSDADLV VFLSPLTTFQ DQLNRRGEFI QEIRRQLEAC QRERAFSVKF EVQAPRWGNP RALSFVLSSL QLGEGVEFDV LPAFDALGQL TGSYKPNPQI YVKLIEECTD LQKEGEFSTC FTELQRDFLK QRPTKLKSLI RLVKHWYQNC KKKLGKLPPQ YALELLTVYA WERGSMKTHF NTAQGFRTVL ELVINYQQLC IYWTKYYDFK NPIIEKYLRR QLTKPRPVIL DPADPTGNLG GGDPKGWRQL AQEAEAWLNY PCFKNWDGSP VSSWILLVRP PA (1-351 aa encoded by BC000562)

Target Information

OAS1 is an interferon inducible protein that may play a role in mediating resistance to virus infection, control of cell growth, differentiation, and apoptosis. It binds double-stranded RNA and polymerizes ATP into PPP(A2'P5'A)N oligomers, which activate the latent RNase L that, when activated, cleaves single-stranded RNAs. This protein is associated with different subcellular fractions such as mitochondrial, nuclear, and rough/smooth microsomal fractions.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Myxovirus resistance protein A inhibits hepatitis C virus replication through JAK-STAT pathway activation.

Archives of virology

Wang H,Xin X,Wang M,Han L,Li J,Hao Y,Zheng C,Shen C

Fri Jun 01 00:00:00 EDT 2018

STAT1 and NF-κB Inhibitors Diminish Basal Interferon-Stimulated Gene Expression and Improve the Productive Infection of Oncolytic HSV in MPNST Cells.

Molecular cancer research : MCR

Jackson JD,Markert JM,Li L,Carroll SL,Cassady KA

Sun May 01 00:00:00 EDT 2016

Bioinformatics

Protein Aliases: (2-5')oligo(A) synthase 1; (2-5')oligo(A) synthase 1A; (2-5')oligo(A) synthetase 1; (2-5')oligo(A) synthetase 1A; 2',5'-oligo A synthetase 1; 2',5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5' oligoadenylate synthetase 1G; 2'-5'-oligoadenylate synthase 1; 2'-5'-oligoadenylate synthase 1A; 2'-5'-oligoadenylate synthetase 1; 2'-5'-oligoadenylate synthetase 1, 40/46kDa; 2'-5'-oligoisoadenylate synthetase 1; 2-5A synthase 1; 2-5A synthase 1A; 2-5A synthetase 1; 2-5A synthetase 1A; 25 oligoadenylate synthetase; E16 (2'-5') oligo A synthetase; E18/E16; IFI 4; IFI4; OAS 1; p42 OAS; p46/p42 OAS

Gene Aliases: E18/E16; IFI-4; L3; OAS1; Oas1a; Oas1g; OIAS; Oias1; OIASI

UniProt ID: (Human) P00973, (Rat) Q05961, (Mouse) P11928

Entrez Gene ID: (Human) 4938, (Rat) 192281, (Mouse) 246730

Molecular Function: nucleotidyltransferase