This antibody is specific to isoform p71 and isoform p69 of OAS2.
This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates. These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: (2'-5')oligo(A) synthetase 2; (2-5')oligo(A) synthase 2; 2',5'-oligoadenylate synthetase-like 11; 2'-5' oligoadenylate synthetase-like 11; 2'-5'-oligoadenylate synthase 2; 2'-5'-oligoadenylate synthetase 2, 69/71kDa; 2,5-oligoadenylate synthetase-like 11; 2-5A synthase 2; A synthetase 2; MGC78578; p69 OAS / p71 OAS; p69OAS / p71OAS
Gene Aliases: OAS2; Oasl11
Molecular Function: nucleotidyltransferase