Positive controls that may be used include: Human Liver Tissue Lysate, Human Liver Tissue Slide
AP9609c is a liver-specific member of the organic anion transporter family. This protein is a transmembrane receptor that mediates the sodium-independent uptake of numerous endogenous compounds including bilirubin, 17-beta-glucuronosyl estradiol and leukotriene C4. This protein is also involved in the removal of drug compounds such as statins, bromosulfophthalein and rifampin from the blood into the hepatocytes. Polymorphisms in the gene encoding this protein are associated with impaired transporter function.
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Protein Aliases: Liver-specific organic anion transporter 1; LST-1; OATP-2; OATP-C; SLC01B1; Sodium-independent organic anion-transporting polypeptide 2; solute carrier family 21 (organic anion transporter), member 6; Solute carrier family 21 member 6; Solute carrier organic anion transporter family member 1B1; solute carrier organic anion transporter family, member 1B1
Gene Aliases: HBLRR; LST-1; LST1; OATP-C; OATP1B1; OATP2; OATPC; SLC21A6; SLCO1B1
UniProt ID: (Human) Q9Y6L6
Entrez Gene ID: (Human) 10599
Molecular Function: transporter