OAZ1 catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. This protein play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein expression is auto-regulated by polyamine-enhanced translational frameshifting.
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Protein Aliases: antizyme 1; AZ1; ODC-Az; Ornithine decarboxylase antizyme 1
Gene Aliases: Antizyme; AZ-1; AZ1; AZI; OAZ; OAZ1; ODC-Az
Molecular Function: protein-binding activity modulator