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OAZ1 Antibody (PA5-14385) in IHC (P)
Immunohistochemistry analysis of OAZ1 in formalin-fixed and paraffin-embedded mouse heart tissue. Samples were incubated with OAZ1 polyclonal antibody (Product # PA5-14385) which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
Product Details
PA5-14385
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 2-31 amino acids from the N-terminal region of human OAZ1
Conjugate
Unconjugated
Form
Liquid
Concentration
0.5 mg/mL
Purification
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2156013
Target Information
OAZ1 catalyzes the conversion of ornithine to putrescine in the first and apparently rate-limiting step in polyamine biosynthesis. This protein play a role in the regulation of polyamine synthesis by binding to and inhibiting ornithine decarboxylase. The protein expression is auto-regulated by polyamine-enhanced translational frameshifting.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: antizyme 1; AZ1; ODC-Az; Ornithine decarboxylase antizyme 1
Gene Aliases: Antizyme; AZ-1; AZ1; AZI; OAZ; OAZ1; ODC-Az; ODCAC
UniProt ID: (Human) P54368, (Mouse) P54369, (Rat) P54370
Entrez Gene ID: (Human) 4946, (Mouse) 18245, (Rat) 25502
regulation of cellular amino acid metabolic process
polyamine biosynthetic process
transport
negative regulation of catalytic activity
positive regulation of protein catabolic process
positive regulation of intracellular protein transport
negative regulation of polyamine transmembrane transport
polyamine metabolic process
negative regulation of protein homodimerization activity
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