Search Thermo Fisher Scientific
Search Thermo Fisher Scientific
Applications | Tested Dilution | Publications |
---|---|---|
Western Blot (WB) |
1:2,000-1:12,000 | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:10-1:100 | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
Product Specifications | |
---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
OBFC2B Fusion Protein Ag6532 (1-211 aa encoded by BC001079) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.3 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Immunogen sequence: MTTETFVKD IKPGLKNLNL IFIVLETGRV TKTKDGHEVR TCKVADKTGS INISVWDDVG NLIQPGDIIR LTKGYASVFK GCLTLYTGRG GDLQKIGEFC MVYSEVPNFS EPNPEYSTQQ APNKAVQNDS NPSASQPTTG PSAASPASEN QNGNGLSAPP GPGGGPHPPH TPSHPPSTRI TRSQPNHTPA GPPGPSSNPV SNGKETRRSS KR (1-211 aa encoded by BC001079)
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: hSSB1; LP3587; Nucleic acid-binding protein 2; oligonucleotide/oligosaccharide-binding fold containing 2B; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; single strand DNA-binding protein 1; Single-stranded DNA-binding protein 1; SOSS complex subunit B1; SOSS-B1
Gene Aliases: 2610036N15Rik; hSSB1; LP3587; NABP2; OBFC2B; RGD1308158; SOSS-B1; SSB1
UniProt ID: (Human) Q9BQ15, (Mouse) Q8R2Y9, (Rat) Q3SWT1
Entrez Gene ID: (Human) 79035, (Mouse) 69917, (Rat) 362813
Molecular Function:
nucleic acid metabolism protein
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