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Product Details
14809-1-AP
| Applications | Tested Dilution | Publications |
|---|---|---|
Western Blot (WB) |
1:2,000-1:12,000 | View 1 publication 1 publication |
Immunohistochemistry (Paraffin) (IHC (P)) |
1:20-1:200 | - |
Immunocytochemistry (ICC/IF) |
1:10-1:100 | - |
Immunoprecipitation (IP) |
0.5-4.0 µg | - |
| Product Specifications | |
|---|---|
Species Reactivity |
Human, Mouse, Rat |
Published species |
Human |
Host/Isotype |
Rabbit / IgG |
Class |
Polyclonal |
Type |
Antibody |
Immunogen |
OBFC2B Fusion Protein Ag6532 (1-211 aa encoded by BC001079) |
Conjugate |
Unconjugated |
Form |
Liquid |
Concentration |
0.3 mg/mL |
Purification |
Antigen affinity chromatography |
Storage buffer |
PBS, pH 7.3, with 50% glycerol |
Contains |
0.02% sodium azide |
Storage conditions |
-20°C |
Product Specific Information
Immunogen sequence: MTTETFVKD IKPGLKNLNL IFIVLETGRV TKTKDGHEVR TCKVADKTGS INISVWDDVG NLIQPGDIIR LTKGYASVFK GCLTLYTGRG GDLQKIGEFC MVYSEVPNFS EPNPEYSTQQ APNKAVQNDS NPSASQPTTG PSAASPASEN QNGNGLSAPP GPGGGPHPPH TPSHPPSTRI TRSQPNHTPA GPPGPSSNPV SNGKETRRSS KR (1-211 aa encoded by BC001079)
Target Information
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: hSSB1; LP3587; Nucleic acid-binding protein 2; oligonucleotide/oligosaccharide-binding fold containing 2B; Oligonucleotide/oligosaccharide-binding fold-containing protein 2B; Sensor of single-strand DNA complex subunit B1; Sensor of ssDNA subunit B1; single strand DNA-binding protein 1; Single-stranded DNA-binding protein 1; SOSS complex subunit B1; SOSS-B1
Gene Aliases: 2610036N15Rik; hSSB1; LP3587; NABP2; OBFC2B; RGD1308158; SOSS-B1; SSB1
UniProt ID: (Human) Q9BQ15, (Mouse) Q8R2Y9, (Rat) Q3SWT1
Entrez Gene ID: (Human) 79035, (Mouse) 69917, (Rat) 362813
Molecular Function:
nucleic acid metabolism protein
double-strand break repair via homologous recombination
DNA repair
cellular response to DNA damage stimulus
mitotic cell cycle checkpoint
response to ionizing radiation
snRNA transcription from RNA polymerase II promoter
regulation of telomerase activity
establishment of protein localization to telomere
positive regulation of telomere capping
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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