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Proteintech
OGDH Polyclonal Antibody
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FIGURE: 1 / 17
OGDH Antibody (15212-1-AP) in ICC/IF
Immunofluorescent analysis of ( 4% PFA) fixed HeLa cells stained for OGDH rabbit pAb (15212-1-AP) at dilution of 1:50 and alpha Tubulin mouse mAb (66031-1-IG) at dilution of 1:100, further stained with Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L) for 15212-1-AP, and Alexa Fluor 594-conjugated AffiniPure Goat Anti-mouse IGG (H+L) for 66031-1-IG.
Product Details
15212-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat,
Sheep
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
OGDH Fusion Protein Ag7368 (674-1023 aa encoded by BC004964)
Conjugate
Form
Liquid
Concentration
0.18 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
This antibody is immunized with the C-terminal and can recognize the isoform 1 and 2 with the MW of 116 kDa.
Immunogen sequence: SGQDVERGT FSHRHHVLHD QNVDKRTCIP MNHLWPNQAP YTVCNSSLSE YGVLGFELGF AMASPNALVL WEAQFGDFHN TAQCIIDQFI CPGQAKWVRQ NGIVLLLPHG MEGMGPEHSS ARPERFLQMC NDDPDVLPDL KEANFDINQL YDCNWVVVNC STPGNFFHVL RRQILLPFRK PLIIFTPKSL LRHPEARSSF DEMLPGTHFQ RVIPEDGPAA QNPENVKRLL FCTGKVYYDL TRERKARDMV GQVAITRIEQ LSPFPFDLLL KEVQKYPNAE LAWCQEEHKN QGYYDYVKPR LRTTISRAKP VWYAGRDPAA APATGNKKTH LTELQRLLDT AFDLDVFKNF S (674-1023 aa encoded by BC004964)
Target Information
This gene encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitocondrial matrix and uses thiamine pyrophosphate as a cofactor. A congential deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: 2-oxoglutarate dehydrogenase complex component E1; 2-oxoglutarate dehydrogenase E1 component, mitochondrial; 2-oxoglutarate dehydrogenase, mitochondrial; Alpha-ketoglutarate dehydrogenase; Alpha-KGDH-E1; E1o; OGDC-E1; oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide); oxoglutarate decarboxylase; oxoglutarate dehydrogenase (lipoamide); oxoglutarate dehydrogenase (succinyl-transferring); testicular tissue protein Li 131; Thiamine diphosphate (ThDP)-dependent 2-oxoglutarate dehydrogenase
Gene Aliases: 2210403E04Rik; 2210412K19Rik; AA409584; AKGDH; d1401; E1k; Kiaa4192; mKIAA4192; OGDC; OGDH; Ogdhl
UniProt ID: (Human) Q02218, (Mouse) Q60597, (Rat) Q5XI78
Entrez Gene ID: (Human) 4967, (Mouse) 18293, (Rat) 360975
oxoglutarate dehydrogenase (succinyl-transferring) activity
thiamine pyrophosphate binding
heat shock protein binding
oxoglutarate dehydrogenase (NAD+) activity
metal ion binding
chaperone binding
oxidoreductase activity
oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
dehydrogenase
generation of precursor metabolites and energy
glycolytic process
tricarboxylic acid cycle
2-oxoglutarate metabolic process
succinyl-CoA metabolic process
lysine catabolic process
NADH metabolic process
cerebellar cortex development
striatum development
hippocampus development
thalamus development
pyramidal neuron development
tangential migration from the subventricular zone to the olfactory bulb
glyoxylate metabolic process
olfactory bulb mitral cell layer development
metabolic process
oxidation-reduction process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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