Activation of the kappa-opioid receptor oppposes a variety of µ-opioid receptor mediated actions throughout the brain and spinal cord. In general, opioids modulate numerous central and peripheral processes, including pain perception, neuroendocrine secretion and the immune response. The opioid signal is transduced from receptors through G proteins to various different effectors. Subsequent to G protein activation, several effectors are known to orchestrate the opioid signal. For example, activation of opioid receptors increases phosphatidylinositol turnover, activates K+ channels and reduces adenylyl cyclase and Ca++ channels activities.
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Protein Aliases: K-OR-1; kappa 1; Kappa opioid receptor; kappa-1; Kappa-type opioid receptor; KOR; KOR-1; MSL-1; Opiate receptor; Opiate receptor, kappa-1; Opioid receptor; Opioid receptor kappa; opioid receptor, kappa 1; opioid receptor, kappa 2; OPRK; OPRK1; Ork1
Gene Aliases: K-OR-1; KOR; KOR-1; MSL-1; OPRK; OPRK1; Oprk2; R21; Ror-d