Recommended positive controls: H1299.
Predicted reactivity: Mouse (94%), Rat (94%), Zebrafish (80%), Chicken (88%), Rhesus Monkey (99%), Bovine (97%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Antigen stimulation of immune cells triggers Ca++ entry through Ca++ release-activated Ca++ (CRAC) channels. ORAI2 is one of two mammalian homologs to ORAI1, a recently identified four-transmembrane spanning protein that is an essential component of CRAC. Like ORAI1, ORAI2 has been shown to function as a highly selective Ca++ plasma membrane channel that is gated through interactions with STIM1, the store-activated endoplasmic reticulum Ca++ sensor, although at a lesser efficacy than ORAI1.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: calcium release-activated calcium channel 2; calcium release-activated calcium modulator 2 protein; CAP-binding protein complex interacting protein 2; CAP-binding protein complex-interacting protein 2; H_NH0514P08.8; Protein orai-2; putative protein ORAI2-2; Transmembrane protein 142B
Gene Aliases: A730041O15Rik; C7orf19; CBCIP2; MEM142B; ORAI2; PP1729; RGD1310213; TMEM142B