Immunogen sequence: MATSSMSKGC FVFKPNSKKR KISLPIEDYF NKGKNEPEDS KLRFETYQLI WQQMKSENER LQEELNKNLF DNLIEFLQKS HSGFQKNSRD LGGQIKLREI PTAALVLGVN VTDHDLTFGS LTEALQNNVT PYVVSLQAKD CPDMKHFLQK LISQLMDCCV DIKSKEEESV HVTQRKTHYS MDSLSSWYMT VTQKTDPKML SKKRTTSSQW QSPPVVVILK DMESFATKVL QDFIIISSQH; Positive Samples: LO2, 293T, HeLa, Mouse liver; Cellular Location: Nucleus
Histone deacetylase 2 (HDAC2), or transcriptional regulator homolog RPD3 L1, is highly homologous to the yeast transcription factor RPD3 (reduced potassium dependency 3) gene. As in yeast, human HDA2 is likely to be involved in regulating chromatin structure during transcription. It has been implicated to associate with YY1, a mammalian zinc-finger transcription factor, which negatively regulates transcription by tethering RPD3 to DNA as a cofactor. This process is highly concerved from yeast to human.
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Protein Aliases: homolog of latheo, Drosophila; IMAGE50150; origin of replication 3 homolog; Origin recognition complex subunit 3; Origin recognition complex subunit Latheo; origin recognition complex, subunit 3 honolog; origin recognition complex, subunit 3-like; OTTHUMP00000040611; RP3-486L4.1
Gene Aliases: LAT; LATHEO; ORC3; ORC3L