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Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The membrane-bound protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized.
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Protein Aliases: ORP-4; OSBP-related protein 4; oxysterol binding protein-like 1; Oxysterol-binding protein 2; Oxysterol-binding protein-related protein 4
Gene Aliases: 1700095P05Rik; C630001G20Rik; Gm244; HLM; KIAA1664; ORP-4; ORP4; OSBP2; OSBPL1; OSBPL4; RGD1309479
UniProt ID: (Human) Q969R2, (Mouse) Q5QNQ6
Entrez Gene ID: (Human) 23762, (Rat) 305475, (Mouse) 74309
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