Oxysterols are byproducts of cholesterol that can have cytotoxic effects on many cell types. The membrane-bound protein encoded by this gene contains a pleckstrin homology (PH) domain and an oxysterol-binding region. It binds oxysterols such as 7-ketocholesterol and may inhibit their cytotoxicity. Alternate transcriptional splice variants have been observed but have not been fully characterized.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ORP-4; OSBP-related protein 4; oxysterol binding protein-like 1; Oxysterol-binding protein 2; Oxysterol-binding protein-related protein 4
Gene Aliases: 1700095P05Rik; C630001G20Rik; Gm244; HLM; KIAA1664; ORP-4; ORP4; OSBP2; OSBPL1; OSBPL4; RGD1309479