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Proteintech
OSM Polyclonal Antibody
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
Product Details
27792-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
OSM Fusion Protein Ag27093 (26-221 aa encoded by BC011589)
Conjugate
Unconjugated
Unconjugated
Unconjugated
Form
Liquid
Concentration
0.27 mg/mL
Amount
40.5 µg
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: AAIGSCSKE YRVLLGQLQK QTDLMQDTSR LLDPYIRIQG LDVPKLREHC RERPGAFPSE ETLRGLGRRG FLQTLNATLG CVLHRLADLE QRLPKAQDLE RSGLNIEDLE KLQMARPNIL GLRNNIYCMA QLLDNSDTAE PTKAGRGASQ PPTPTPASDA FQRKLEGCRF LHGYHRFMHS VGRVFSKWGE SPNRSRR (26-221 aa encoded by BC011589)
Target Information
Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi's sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi's sarcoma cells, but inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptors in hepatoma cells. OSM shares several structural and functional characteristics with LIF, IL-6, and CNTF.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: MGC20461; OSM
UniProt ID: (Human) P13725, (Rat) Q65Z15
Entrez Gene ID: (Human) 5008, (Rat) 289747
positive regulation of acute inflammatory response
immune response
cell proliferation
positive regulation of cell proliferation
negative regulation of cell proliferation
regulation of cell communication
regulation of signaling
positive regulation of interleukin-17 production
positive regulation of peptidyl-serine phosphorylation
oncostatin-M-mediated signaling pathway
positive regulation of tyrosine phosphorylation of STAT protein
positive regulation of MAPK cascade
positive regulation of transcription from RNA polymerase II promoter
negative regulation of hormone secretion
positive regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of protein kinase B signaling
regulation of hematopoietic stem cell differentiation
tyrosine phosphorylation of STAT protein
peripheral nervous system development
response to heat
negative regulation of meiotic nuclear division
behavioral response to pain
positive regulation of apoptotic signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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