Orexin B is a neuropeptides that play a significant role in the regulation of food intake and sleep-wakefulness, possibly by coordinating the complex behavioral and physiologic responses of these complementary homeostatic functions. A broader role in the homeostatic regulation of energy metabolism, autonomic function, hormonal balance and the regulation of body fluids, is also suggested. Orexin-A binds to both OX1R and OX2R with a high affinity, whereas orexin-B binds only to OX2R with a similar high affinity.
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Protein Aliases: Hcrt; Hcrt1; Hcrt2; Hypocretin; hypocretin (orexin) neuropeptide; Hypocretin-1; Hypocretin-2; Orexin; Orexin-A; Orexin-B; prepro-orexin
Gene Aliases: HCRT; NRCLP1; OX; PPORX; PPOX
UniProt ID: (Human) O43612
Entrez Gene ID: (Human) 3060