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P2RX6 Polyclonal Antibody
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Product Details
BS-12110R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human P2RX6, amino acids 55-160.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
P2rx6 encodes receptors that are members of the ligand-gated ion channel family that open in response to extracellular ATP. Each P2rx6 receptor is made up of a trimer of subunits (P2X1-7) all of which share the common structure of two transmembrane domains. The protein encoded by the P2rx6 gene belongs to the family of P2X receptors, which are ATP-gated ion channels and mediate rapid and selective permeability to cations. The P2rx6 gene is predominantly expressed in skeletal muscle, and regulated by p53. The encoded protein is associated with VE-cadherin at the adherens junctions of human umbilical vein endothelial cells. Alternative splicing results in multiple transcript variants of P2rx6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP receptor; P2RXL1; P2X purinoceptor 6; P2X6; P2X6 receptor; P2XM; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 6; Purinergic receptor P2X-like 1; purinergic receptor P2X-like 1 orphan receptor; purinergic receptor P2X-like 1, orphan receptor; purinergic receptor P2X6; purinoceptor P2X6; purinoreceptor P2X6; skeletal muscle-expressed P2X
Gene Aliases: P2RX6; P2RXL1; P2X6; P2XM; Rnap2x6
UniProt ID: (Human) O15547, (Rat) P51579, (Mouse) O54803
Entrez Gene ID: (Human) 9127, (Rat) 25041, (Mouse) 18440
ion transport
muscle contraction
signal transduction
response to ATP
ion transmembrane transport
purinergic nucleotide receptor signaling pathway
excitatory postsynaptic potential
calcium ion transmembrane transport
cation transmembrane transport
cation transport
protein homooligomerization
protein heterooligomerization
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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