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Invitrogen
P2X1 Polyclonal Antibody
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FIGURE: 1 / 6
P2X1 Antibody (PA5-114312) in IHC (P)
Immunohistochemical analysis of P2X1 in paraffin-embedded human prostate carcinoma tissue using a polyclonal antibody (Product #PA5-114312). The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes. The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with the primary antibody (1:50) for 3... View More
Product Details
PA5-114312
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide within Human P2X1 aa 252-301.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 0.2% BSA, 50% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Target Information
The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with relatively high calcium permeability. Binding to ATP mediates synaptic transmission between neurons and from neurons to smooth muscle, being responsible, for example, for sympathetic vasoconstriction in small arteries, arterioles and vas deferens. Mouse studies suggest that this receptor is essential for normal male reproductive function. It is possible that the development of selective antagonists for this receptor may provide an effective non-hormonal male contraceptive pill.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP receptor; ligand gated ion channel; P2X purinoceptor 1; P2X receptor, subunit 1; P2X1; P2X1 receptor; programmed cell death 3; Purinergic receptor; purinergic receptor P2X, ligand gated ion channel, 1; purinergic receptor P2X1; RP-2 protein; unnamed protein product
Gene Aliases: AI323649; BB122383; P2RX1; P2x; P2X1; P2XMR; Pdcd3; RP-2
UniProt ID: (Human) P51575, (Rat) P47824, (Mouse) P51576
Entrez Gene ID: (Human) 5023, (Rat) 25505, (Mouse) 18436
nucleotide binding
purinergic nucleotide receptor activity
extracellular ATP-gated cation channel activity
ion channel activity
cation channel activity
protein binding
ATP binding
channel activity
identical protein binding
suramin binding
macromolecular complex binding
ligand-gated calcium channel activity
drug binding
zinc ion binding
ligand-gated ion channel
serotonin secretion by platelet
regulation of vascular smooth muscle contraction
ion transport
apoptotic process
regulation of smooth muscle contraction
signal transduction
insemination
regulation of blood pressure
neuronal action potential
regulation of vasoconstriction
calcium-mediated signaling
platelet activation
response to ATP
ion transmembrane transport
synaptic transmission, glutamatergic
purinergic nucleotide receptor signaling pathway
positive regulation of ion transport
ceramide biosynthetic process
establishment of localization in cell
regulation of calcium ion transport
excitatory postsynaptic potential
calcium ion transmembrane transport
cation transmembrane transport
regulation of presynaptic cytosolic calcium ion concentration
positive regulation of calcium ion import across plasma membrane
regulation of synaptic vesicle exocytosis
cation transport
activation of cysteine-type endopeptidase activity involved in apoptotic process
response to organic substance
vasoconstriction
protein homooligomerization
protein heterooligomerization
transport
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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