The target sequence has 99% sequence homology with rat, 98% to bovine, 96% to xenopus and 74% to zebrafish.
Homer 1 (Homer protein homolog 1) belongs to the Homer family of proteins that regulate signal transduction through, and the trafficking of, glutamate receptors, as well as maintain and regulate extracellular glutamate levels in corticolimbic brain regions. The Homer 1 is enriched at excitatory synapses and binds group 1 metabotropic glutamate receptors (mGluRs).
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Protein Aliases: HOMER; 1; homer homolog 1; Homer protein homolog 1; homer, neuronal immediate early gene, 1; Homer-1; HOMER1A; HOMER1B; HOMER1C; immediate early gene protein Homer1A; neuronal immediate early gene; SYN47; VASP/Ena-related gene up-regulated during seizure and LTP 1; Ves-1; Vesl-1
Gene Aliases: HOMER; homer-1; HOMER1; HOMER1A; HOMER1B; HOMER1C; PSD-Zip45; SYN47; Ves-1; vesl-1; Vesl1
Molecular Function: signaling molecule